Ladefoged C
Acta Orthop Scand. 1982 Aug;53(4):581-6. doi: 10.3109/17453678208992262.
A total of 116 osteoarthritic femoral heads were studied with regard to the relationship between amyloid deposits in the cartilage and osteoarthritic changes. All the femoral heads were found to be deformed and only 10 were covered by cartilage over the whole surface. Sixty-five per cent of the femoral heads showed amyloid degeneration of the cartilage surface. The amount of amyloid did not correlate with the extent of the erosion. Neither was there a significant correlation between the amyloid degeneration on the one hand and fibrillation and flaking of the cartilage surface on the other. A reduction in the amount of chondroitin sulphate was observed in all 116 femoral heads to varying degrees, but no correlation with amyloid could be demonstrated. Thus, in the present study no correlation between the morphological and histochemical degrees of osteoarthritis and amyloid has been found. Six out of seven femoral heads with pyrophosphate deposits in the cartilage also contained amyloid.
对116个骨关节炎股骨头进行了研究，以探讨软骨中淀粉样沉积物与骨关节炎变化之间的关系。所有股骨头均有变形，只有10个在整个表面被软骨覆盖。65%的股骨头显示软骨表面有淀粉样变性。淀粉样物质的量与侵蚀程度无关。一方面淀粉样变性与另一方面软骨表面的纤维化和片状剥落之间也没有显著相关性。在所有116个股骨头中均观察到硫酸软骨素含量不同程度的减少，但未发现与淀粉样物质有相关性。因此，在本研究中未发现骨关节炎的形态学和组织化学程度与淀粉样物质之间存在相关性。软骨中有焦磷酸盐沉积的7个股骨头中有6个也含有淀粉样物质。
