Kameyama K
Department of Pathology, School of Medicine, Keio University, Tokyo.
Pathol Res Pract. 1996 Jan;192(1):20-6. doi: 10.1016/S0344-0338(96)80125-7.
To investigate the invasive activity of thyroid cancer, an in situ hybridization study was carried out in 19 thyroid tumors, including nine papillary carcinomas, five follicular carcinomas and five follicular adenomas, by using a 35S-labeled MMP-1 (matrix metalloproteinase-1) cDNA probe. The MMP-1 gene was expressed not in the cancer cells but in the fibrous capsules of papillary carcinoma. Thyroid cancer is generally circumscribed by a fibrous capsule. We found that types I and III collagen constitute the fibrous capsule, and that the MMP-1 gene was expressed in the outer border of these sites. These findings suggest that MMP-1 plays an important role in the invasion of thyroid cancer.
为研究甲状腺癌的侵袭活性，采用35S标记的基质金属蛋白酶-1（MMP-1）cDNA探针，对19例甲状腺肿瘤（包括9例乳头状癌、5例滤泡状癌和5例滤泡性腺瘤）进行了原位杂交研究。MMP-1基因不在癌细胞中表达，而是在乳头状癌的纤维包膜中表达。甲状腺癌通常被纤维包膜所包绕。我们发现I型和III型胶原构成了纤维包膜，且MMP-1基因在这些部位的外边界表达。这些发现提示MMP-1在甲状腺癌的侵袭中起重要作用。
