Shani J, Kushelevsky A P, Harari M, Even-Paz Z
Department of Pharmacology, Hebrew University School of Pharmacy, Jerusalem, Israel.
Pharmacol Res. 1995 Jun;31(6):355-9. doi: 10.1016/1043-6618(95)80089-1.
The diastolic and systolic blood pressure of 1366 psoriatic patients, treated at the Dead Sea for a period of 4 weeks, was monitored from the day following their arrival. The patients were divided into three categories: (a) psoriatics on antihypertensive medication; (b) psoriatics not receiving antihypertensive medication, but whose initial diastolic blood pressure equaled or exceeded 90 mmHg, and (c) psoriatics with normal blood pressure (diastolic pressure lower than 90 mmHg). A paired t-test revealed that the systolic blood pressure of the two hypertensive groups (a and b) dropped by an average of 22 mmHg, and the diastolic blood pressure dropped by 11 and 16 mmHg, respectively. The drop was evident 2 days after their arrival, and leveled off only after 2 weeks. A similar drop in systolic blood pressure was observed in normotensive psoriatics. On the basis of this study it may be concluded that high blood pressure is not a contraindication for the treatment of psoriasis at the Dead Sea.
对1366名在死海接受为期4周治疗的银屑病患者,从他们抵达后的第二天开始监测其舒张压和收缩压。患者被分为三类:(a)正在服用抗高血压药物的银屑病患者;(b)未服用抗高血压药物但初始舒张压等于或超过90 mmHg的银屑病患者;(c)血压正常(舒张压低于90 mmHg)的银屑病患者。配对t检验显示,两个高血压组(a和b)的收缩压平均下降了22 mmHg,舒张压分别下降了11 mmHg和16 mmHg。这种下降在他们抵达后2天就很明显,并且仅在2周后才趋于平稳。血压正常的银屑病患者也观察到了类似的收缩压下降情况。基于这项研究,可以得出结论,高血压并非在死海治疗银屑病的禁忌证。