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潜水层水对黑色素合成的抑制作用。 （你提供的原文“with phreatic water”表述不太准确，推测可能是想表达“潜水层水”相关内容，按此理解进行了翻译）

Inhibitory effects of with phreatic water on melanin synthesis.

作者信息

Jang Moon-Hee, Ahn Taek-Won

机构信息

Department of Sasang Constitutional Medicine, Cheonan Oriental Hospital of Daejeon University, Cheonan, Korea.

Hot Spring Medicine Laboratory, Daejeon University, Cheonan, Korea.

出版信息

Integr Med Res. 2015 Jun;4(2):76-93. doi: 10.1016/j.imr.2014.08.001. Epub 2014 Aug 30.

DOI:10.1016/j.imr.2014.08.001
PMID:28664113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5481772/
Abstract

BACKGROUND

Recently, people have begun showing heightened interest in skin whitening. Melanin is an important factor that determines skin color. The purpose of this study is to investigate the inhibitory effect of (TAM) with phreatic water (PW) from Dogo Hot Springs on melanin synthesis.

METHODS

We assessed the inhibitory effects of TAM on melanin synthesis in B16F10 mouse melanoma cells. The mRNA levels of tyrosinase related protein (TRP)-1, TRP-2, tyrosinase, MITF, ERK, and PKA protein were analyzed with reverse transcription polymerase chain reaction and Western blot analysis. We also assessed the inhibitory effects of TAM with PW on melanin synthesis in HRM-2 melanin-possessing hairless mice. After UVB irradiation, differences in melanin were analyzed with an image analysis software between the left dorsal skin (untreated part) and the right dorsal skin (treated part). The mRNA levels of TRP-1, TRP-2, and matrix metalloproteinase (MMP)-9 were analyzed with real-time quantitative polymerase chain reaction. The dorsal skins were analyzed with histological test by hematoxylin and eosin staining.

RESULTS

TAM inhibited the TRP-1, TRP-2, tyrosinase, MITF mRNA gene expression, and PKA protein expression on the concentration-dependent B16F10 cell. Moreover, TAM increased the ERK mRNA gene expression in the B16F10 cell. After UVB irradiation, TAM with PW increased the differences in melanin between the left dorsal skin (untreated part) and the right dorsal skin (treated part) in HRM-2 mice. TAM with PW inhibited the TRP-1, TRP-2, and MMP-9 mRNA gene expression in HRM-2 mice. TAM with PW decreased the epidermal thickness, around the cell deformation, keratinization, and infiltration in HRM-2 mice.

CONCLUSION

These results indicate that TAM with PW has the inhibitory effect of decreasing the melanin synthesis.

摘要

背景

最近，人们对皮肤美白的兴趣日益浓厚。黑色素是决定肤色的一个重要因素。本研究的目的是探讨多戈温泉潜水层水（PW）与曲美替尼（TAM）对黑色素合成的抑制作用。

方法

我们评估了TAM对B16F10小鼠黑色素瘤细胞黑色素合成的抑制作用。用逆转录聚合酶链反应和蛋白质免疫印迹分析酪氨酸酶相关蛋白（TRP）-1、TRP-2、酪氨酸酶、小眼畸形相关转录因子（MITF）、细胞外信号调节激酶（ERK）和蛋白激酶A（PKA）蛋白的mRNA水平。我们还评估了TAM与PW对HRM-2有黑色素的无毛小鼠黑色素合成的抑制作用。紫外线B（UVB）照射后，用图像分析软件分析左背部皮肤（未处理部分）和右背部皮肤（处理部分）之间黑色素的差异。用实时定量聚合酶链反应分析TRP-1、TRP-2和基质金属蛋白酶（MMP）-9的mRNA水平。用苏木精和伊红染色进行组织学检测分析背部皮肤。

结果

TAM在浓度依赖性的B16F10细胞上抑制TRP-1、TRP-2、酪氨酸酶、MITF mRNA基因表达和PKA蛋白表达。此外，TAM增加了B16F10细胞中ERK mRNA基因表达。UVB照射后，TAM与PW增加了HRM-2小鼠左背部皮肤（未处理部分）和右背部皮肤（处理部分）之间黑色素的差异。TAM与PW抑制了HRM-2小鼠中TRP-1、TRP-2和MMP-9 mRNA基因表达。TAM与PW减少了HRM-2小鼠的表皮厚度、细胞变形、角质化和浸润。

结论

这些结果表明，TAM与PW具有减少黑色素合成的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/39fe4c8695d8/gr17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/f580f7a252a6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/2b3e1aa91ff2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/0813dc41d66f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/652706038e1b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/5e41c4522cc3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/02a5bc4b93e0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/a8dc69427702/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/d12893195f43/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/bbe3042f7443/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/8604c23c71aa/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/af61348f5800/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/9f3a06910240/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/93f4bd71d7f1/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/5e71ab48c4b1/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/50a55487fe26/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/d98695f01e24/gr16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/39fe4c8695d8/gr17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/f580f7a252a6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/2b3e1aa91ff2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/0813dc41d66f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/652706038e1b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/5e41c4522cc3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/02a5bc4b93e0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/a8dc69427702/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/d12893195f43/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/bbe3042f7443/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/8604c23c71aa/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/af61348f5800/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/9f3a06910240/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/93f4bd71d7f1/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/5e71ab48c4b1/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/50a55487fe26/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/d98695f01e24/gr16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a5/5481772/39fe4c8695d8/gr17.jpg

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Photochem Photobiol. 2010 Jul-Aug;86(4):955-63. doi: 10.1111/j.1751-1097.2010.00751.x. Epub 2010 May 21.
2
Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice.姜黄提取物（姜黄）对黑色素无毛小鼠慢性紫外线 B 照射诱导皮肤损伤的影响。
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3
Molecules. 2021 Dec 21;27(1):3. doi: 10.3390/molecules27010003.
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4
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5
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Neoplasia. 2006 Jul;8(7):543-50. doi: 10.1593/neo.05655.
6
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7
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8
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