Vulpis V, Seccia T M, Nico B, Ricci S, Roncali L, Pirrelli A
DIMO, Department of Biomedical Sciences and Human Oncology, University of Bari, Italy.
Pharmacol Res. 1995 Jun;31(6):375-81. doi: 10.1016/1043-6618(95)80092-1.
The aim of this study is to investigate the effects of two ACE-inhibitors with different chemical formulae, cilazapril (CLZ) and captopril (CPT), on left ventricular myocardiocytes from spontaneously hypertensive rats (SHR), characterized by ultrastructural alterations associated with left ventricular hypertrophy, and from Wistar-Kyoto (WKY) rats, considered as controls. After CLZ-treatment, not remarkable changes are observed in WKY myocardiocytes, whereas SHR ones show a considerable reduction in their original alterations in ultrastructure. After CPT-treatment, both SHR and WKY myocardiocytes are altered in ultrastructure. The morphometric investigation confirms that CPT and CLZ produce different effects. Even if the drugs induce a similar decrease in blood pressure and left ventricular mass index, CLZ unlike CPT seems to improve the ultrastructural abnormalities associated with left ventricular hypertrophy. These changes could be related to the different chemical structure of CLZ and CPT, or to a different affinity of the two drugs for the local renin-angiotensin system.
本研究旨在探讨两种化学式不同的血管紧张素转换酶抑制剂（ACE 抑制剂）——西拉普利（CLZ）和卡托普利（CPT），对自发性高血压大鼠（SHR）左心室心肌细胞以及作为对照的Wistar-Kyoto（WKY）大鼠左心室心肌细胞的影响。SHR的特征为伴有左心室肥厚的超微结构改变。CLZ治疗后，WKY心肌细胞未观察到明显变化，而SHR心肌细胞的原始超微结构改变则有显著减轻。CPT治疗后，SHR和WKY心肌细胞的超微结构均发生改变。形态学研究证实CPT和CLZ产生了不同的效应。即使这两种药物能使血压和左心室质量指数出现相似程度的降低，但与CPT不同，CLZ似乎改善了与左心室肥厚相关的超微结构异常。这些变化可能与CLZ和CPT的化学结构不同有关，也可能与这两种药物对局部肾素-血管紧张素系统的不同亲和力有关。
