Vulpis V, Roncali L, Bertossi M, Nico B, Seccia T, Ricci S, Pirrelli A
Patologia Medica II, Servizio Ipertensione Arteriosa, Università di Bari, Italia.
Cardiology. 1994;84(1):14-24. doi: 10.1159/000176324.
The ACE inhibitors cilazapril and captopril were administered at 10 and 100 mg/day, respectively, to spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY) from the 12th to the 22nd week of life. Both drugs produced statistically significant reductions in systolic and diastolic blood pressure, left-ventricular mass and index of left-ventricular hypertrophy in SHR. After cilazapril treatment, the morphology of SHR cardiocytes became similar to that in untreated normotensive rats, while in captopril-treated rats, myofibrils were disarranged, obliquely oriented and smaller than normal, with areas of electron-transparent sarcoplasm separating the myofibril bundles; mitochondria were also altered. In WKY rats, we observed no statistically significant changes in blood pressure, ventricular weight and hypertrophy index between the two drugs; however, there were different effects of the two drugs on the ultrastructural morphology of the myocardium. These observations suggest that these two molecularly dissimilar ACE inhibitors act differently at the tissue level despite similar effects on blood pressure and left-ventricular mass.
从出生后第12周龄至22周龄，分别给予自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto大鼠（WKY）口服西拉普利和卡托普利，剂量分别为每日10毫克和100毫克。两种药物均使SHR的收缩压和舒张压、左心室质量以及左心室肥厚指数出现具有统计学意义的下降。经西拉普利治疗后，SHR心肌细胞的形态变得与未经治疗的正常血压大鼠相似，而在卡托普利治疗的大鼠中，肌原纤维排列紊乱、呈斜向排列且比正常的小，肌原纤维束之间有电子透明的肌浆区域分隔；线粒体也发生了改变。在WKY大鼠中，两种药物之间的血压、心室重量和肥厚指数无统计学显著变化；然而，两种药物对心肌超微结构形态有不同影响。这些观察结果表明，尽管这两种分子结构不同的ACE抑制剂对血压和左心室质量有相似作用，但它们在组织水平的作用方式不同。
