Wu G
Clinical Pharmacology and Toxicology Service, Medical School, University of Udine, Italy.
Pharmacol Res. 1995 Jun;31(6):393-9. doi: 10.1016/1043-6618(95)80095-6.
The method proposed by Sheiner and Beal plays a cornerstone role in the evaluation of the predictive performance. Recently, the Sheiner and Beal's method has been intensively used in pharmacokinetic studies, however, this method has been used in a somewhat confusing way by several authors. Therefore, if one wants to use this method, one might find different examples to follow in the pharmacokinetic literature. Meanwhile, several detailed points were not given by Sheiner and Beal in their original paper. Clearly, the principles suggested by Sheiner and Beal are simple, but the practical application is something of an art. In this work we addressed these detailed points and indicated the confusion in using the Sheiner and Beal's method.
Sheiner和Beal提出的方法在预测性能评估中起着基石作用。最近，Sheiner和Beal的方法在药代动力学研究中得到了广泛应用，然而，几位作者对该方法的使用方式有些混乱。因此，如果有人想使用这种方法，可能会在药代动力学文献中找到不同的示例。同时，Sheiner和Beal在他们的原始论文中没有给出几个详细的要点。显然，Sheiner和Beal提出的原则很简单，但实际应用却是一门艺术。在这项工作中，我们阐述了这些详细要点，并指出了使用Sheiner和Beal方法时存在的混乱。
