Güttler F, Wamberg E
Acta Paediatr Scand. 1977 May;66(3):339-44. doi: 10.1111/j.1651-2227.1977.tb07904.x.
Of 488 006 neonates tested by Guthrie screening 58 showed values above 2.5 mg/100 ml. Thirty-two showed values between 2.5 mg/100 ml and 15 mg/100 ml. Eighteen of these infants appeared to have phenylketonuria (PKU) and fourteen to have persistent hyperphenylalaninemia (HPA). Neither the initial Guthrie test-value nor the confirmatory test were able to differentiate between these two conditions. Consequently a phenylalanine restricted diet is started in any child with serumphenylalanine values exceeding 10 mh/100 ml (605 micronmol/l). The data show that the course of the dietary tolerance of phenylalanine and a 24-hour phenylalanine load test will differentiate infants with PKU from those with HPA.
在通过古思里筛查测试的488006名新生儿中，有58名的数值高于2.5毫克/100毫升。32名的数值在2.5毫克/100毫升至15毫克/100毫升之间。这些婴儿中有18名似乎患有苯丙酮尿症（PKU），14名患有持续性高苯丙氨酸血症（HPA）。最初的古思里测试值和确诊测试都无法区分这两种情况。因此，对于任何血清苯丙氨酸值超过10毫克/100毫升（605微摩尔/升）的儿童，都开始采用限制苯丙氨酸饮食。数据表明，苯丙氨酸饮食耐受性的过程和24小时苯丙氨酸负荷试验将区分患有PKU的婴儿和患有HPA的婴儿。
