Herbert J, Goodyer I M, Altham P M, Pearson J, Secher S M, Shiers H M
Department of Psychiatry, University of Cambridge.
Psychol Med. 1996 Mar;26(2):257-63. doi: 10.1017/s0033291700034656.
The association between high evening cortisol and low morning DHEA and the pattern of co-morbid diagnoses in 82 cases of major depressive disorder in 8- to 16-year-olds has been analysed. There was a significant association between the presence of high evening cortisol and co-morbid dysthymia. This was independent of age or sex. No positive association was found between the presence of low morning DHEA and any co-morbid diagnosis. However, co-morbid panic or phobic disorder was significantly associated with the absence of this endocrine abnormality. These findings suggest that specific endocrine disturbances may be associated with different patterns of co-morbidity during an episode of major depression in this age group.
对82例8至16岁重度抑郁症患者夜间皮质醇水平升高与早晨脱氢表雄酮水平降低之间的关联以及共病诊断模式进行了分析。夜间皮质醇水平升高与共病心境恶劣障碍之间存在显著关联。这与年龄或性别无关。早晨脱氢表雄酮水平降低与任何共病诊断之间未发现正相关。然而，共病惊恐或恐惧症与不存在这种内分泌异常显著相关。这些发现表明，在该年龄组的重度抑郁发作期间，特定的内分泌紊乱可能与不同的共病模式相关。
