van der Knaap M S, van Wezel-Meijler G, Barth P G, Barkhof F, Adèr H J, Valk J
Department of Child Neurology, Free University Hospital, Amsterdam, The Netherlands.
Radiology. 1996 Aug;200(2):389-96. doi: 10.1148/radiology.200.2.8685331.
To provide a practical standard for normal development of gyri and sulci in preterm and term neonates.
Thirty-nine living preterm infants without substantial neurologic problems underwent magnetic resonance (MR) imaging of the brain. Five infants who were born at term but died of a nonneurologic disorder within 1 week and who underwent autopsy were examined after death with MR imaging. Seven cerebral surface areas were defined, and the development of gyri and sulci in each area was assigned a score between 1 and 5.
The postconceptional age (PCA) range of the newborns was 30-42 weeks. When the gyral development scores were assessed as a function of PCA, four transition points could be discerned for the brain as a whole; these transitions occurred at PCAs of 32, 34, 37, and 40 1/2-41 weeks. These four transition points allowed the general gyral development to be divided into five stages. Development of gyri and sulci was most advanced in the area of the central sulcus and the medical occipital area. Development was latest in the frontobasal and frontopolar areas and the anterior part of the temporal lobe.
A simple staging system allows easy assessment of the progress of cerebral gyration and sulcation in preterm and term infants.
为早产儿和足月儿脑回和脑沟的正常发育提供一个实用标准。
39例无严重神经问题的存活早产儿接受了脑部磁共振成像（MR）检查。5例足月儿出生后1周内死于非神经系统疾病并接受尸检的婴儿，死后进行了MR成像检查。定义了7个脑表面区域，并给每个区域脑回和脑沟的发育分配了1至5分。
新生儿的孕龄（PCA）范围为30至42周。当将脑回发育评分作为PCA的函数进行评估时，整个大脑可识别出四个转变点；这些转变发生在孕龄32、34、37以及40.5至41周时。这四个转变点可将脑回的总体发育分为五个阶段。中央沟区域和枕叶内侧区域的脑回和脑沟发育最成熟。额基底和额极区域以及颞叶前部的发育最晚。
一个简单的分期系统能够轻松评估早产儿和足月儿脑回形成和脑沟形成的进展情况。
