Solé A, Cordero P J, Martínez M E, Vera F
Servicio de Neumología, Hospital Universitario La Fe, Valencia.
Rev Clin Esp. 1996 Feb;196(2):99-102.
A series is here reported of eleven patients with the histological diagnosis of bronchiolitis obliterans with organized pneumonia (BOOP) and the clinical course after one year of corticosteroid therapy. Four patients had idiopathic BOOP, one patient BOOP secondary to bone marrow transplantation and the other six patients had BOOP secondary to inhalation of toxic substances (Ardystil syndrome). The most common radiological feature at the onset of the disease was the presence of bilateral patchy infiltrates; the most common functional finding was a decreased diffusion capacity for carbon monoxide. After one year of follow-up, seven out of the ten patients still alive had a normal radiology and all showed a significant improvement in ventilatory and gasometric parameters.
本文报告了一组11例经组织学诊断为闭塞性细支气管炎伴机化性肺炎（BOOP）的患者以及接受皮质类固醇治疗一年后的临床病程。4例为特发性BOOP，1例为骨髓移植继发的BOOP，另外6例为吸入有毒物质继发的BOOP（阿迪司替综合征）。疾病发作时最常见的放射学特征是双侧斑片状浸润；最常见的功能表现是一氧化碳弥散能力下降。经过一年的随访，10例存活患者中有7例放射学表现正常，且所有患者的通气和气体测量参数均有显著改善。
