[抗埃博拉热免疫球蛋白的特性研究与开发]
[Development and study of the properties of immunoglobulin against Ebola fever].
作者信息
Borisevich I V, Mikhaĭlov V V, Krasnianskiĭ V P, Gradoboev V N, Lebedinskaia E V, Potryvaeva N V, Timan'kova G D
出版信息
Vopr Virusol. 1995 Nov-Dec;40(6):270-3.
PMID:8686265
Abstract
Immunoglobulin to Ebola fever has been for the first time prepared from hyperimmune equine blood sera by alcohol fractionation after Cohn. Preclinical study of the physicochemical and immunobiological properties of immunoglobulin showed that it protects up to 100% Papio hamadryas infected intramuscularly at doses of 110 to 29 LD50 Ebola virus. Scheme for the use of Ebola immunoglobulin has been experimentally validated.
摘要
抗埃博拉热免疫球蛋白首次由经科恩（Cohn）法乙醇分级分离的超免疫马血血清制备而成。对该免疫球蛋白的物理化学和免疫生物学特性进行的临床前研究表明，它能保护高达100%的被以110至29个半数致死剂量（LD50）的埃博拉病毒进行肌肉注射感染的阿拉伯狒狒。埃博拉免疫球蛋白的使用方案已通过实验验证。
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