United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland, MD 21702, USA.
Viruses. 2011 Jul;3(7):982-1000. doi: 10.3390/v3070982. Epub 2011 Jun 27.
Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment.
丝状病毒可引起人类严重的、常致命的出血热。疫苗和治疗药物研发的最新进展为这些感染的治疗提供了令人鼓舞的数据。然而,对于致命性与非致命性丝状病毒感染中的免疫反应,人们知之甚少。本综述总结了有关丝状病毒感染免疫相关性的已发表文献,并强调了我们在这一主题上知识的不足。根据丝状病毒的类型、疫苗接种或药物治疗的存在和时机,很可能存在几种类型的成功免疫反应。