Melikian A G, Shtok A V, Golanov A V, Kazarnovskaia M I, Korshunov A G
Zh Vopr Neirokhir Im N N Burdenko. 1995 Oct-Dec(4):3-10.
Stereotactic computerized technology providing a goal-oriented and low-traumatic access to small intracerebral tumors and their precision microsurgical removal has been developed. A specialized programme implemented on an IBM PC/AT makes a whole set of stereotactic calculations based on computerized tomography (CT). With this, a three-dimensional volumetric tumor reconstruction is conducted by interpolating the tumor outlines which can be seen on consecutive stereotactic CT sections. The system provides laminar visualization of the tumor outlines in the distal aperture plane of an original tubular retractor which makes an access to the tumor and its removal and coincides these sections with the aperture projection. Thus, each discrete unit of tumor volume (minimum 1 cubic mm) proves to be stereotactically oriented against the retractor both in the plane of its aperture and along its trajectory. Examining the images prio and during surgery simulates an operational field, thus computerally supporting the resection of a tumor strictly in the range of CT-defined outlines. A total of 15 patients aged 3 to 52 years who had hemispheric tumors were treated. Five patients presented with cancer metastases (one of them had multiple ones), 7 had gliomas and 1 displayed a radiation necrotic focus at the site of the irradiated glial tumor that was verified by stereotactic biopsy, 2 cases had cavernous angiomas. The use of stereotactic techniques for tumor removal in these patients was determined by their location and small sizes. Eight cases presented with in-depth tumors located in the area of subcortical ganglions, the visual tuber, and the internal bursa. In 7 patients there were a comparatively superficial tumors afflicting the cortex and substantia alba in the projection of central gyri or temporoparietal regions in the predominant hemisphere. The maximum dimensions of tumors varied 10 to 35 mm without exceeding 25 mm in most (14) patients. A small circulatory trephination with a crown cutter, 35 mm in diameter, was employed in the majority of cases (in 13 patients). In 3 cases, there was a slight and transient aggravation of the existing focal symptomatology followed by regression and return to the preoperative values during 5-6 days. Following surgery, 10 had either improved status or no additional iatrogenic defect or they underwent outpatient treatment within 6-7 days after intervention. In 2 cases, a steady-state aggravation of focal symptoms was associated with surgery. Control studies by CT and MRT provided evidence for no residual tumor tissue in all cases except one.
立体定向计算机技术已得到发展,它能为小的脑内肿瘤提供目标导向且低创伤的入路,并能精确地进行显微手术切除。在IBM PC/AT上运行的一个专门程序,可基于计算机断层扫描(CT)进行一整套立体定向计算。通过对在连续立体定向CT切片上可见的肿瘤轮廓进行插值,实现肿瘤的三维体积重建。该系统能在原始管状牵开器的远端口平面上对肿瘤轮廓进行分层可视化,该牵开器用于进入肿瘤并进行切除,且使这些切片与端口投影重合。这样,肿瘤体积的每个离散单元(最小1立方毫米)在其端口平面和沿其轨迹上都能相对于牵开器进行立体定向定位。术前和术中检查图像可模拟手术视野,从而在计算机辅助下严格在CT定义的轮廓范围内切除肿瘤。共治疗了15例年龄在3至52岁的半球肿瘤患者。5例为癌转移(其中1例有多处转移),7例为胶质瘤,1例在经立体定向活检证实的照射胶质肿瘤部位显示放射性坏死灶,2例为海绵状血管瘤。这些患者采用立体定向技术切除肿瘤是由其位置和小尺寸决定的。8例为深部肿瘤,位于皮质下神经节、视结节和内囊区域。7例患者有相对表浅的肿瘤,累及优势半球中央回或颞顶叶区域投影处的皮质和白质。肿瘤的最大尺寸在10至35毫米之间,大多数(14例)患者不超过25毫米。大多数病例(13例患者)采用直径35毫米的冠状切割器进行小的循环开颅术。3例患者现有局灶性症状出现轻微且短暂的加重,随后在5至6天内消退并恢复到术前值。术后,10例患者的状况有所改善,或无额外的医源性缺陷,或在干预后6至7天内接受门诊治疗。2例患者局灶性症状持续加重与手术有关。除1例患者外,CT和磁共振成像(MRT)对照研究表明所有病例均无残留肿瘤组织。