Mellers J D, Sham P, Jones P B, Toone B K, Murray R M
Section of Neuropsychiatry, Institute of Psychiatry, London.
Acta Psychiatr Scand. 1996 Feb;93(2):92-8. doi: 10.1111/j.1600-0447.1996.tb09808.x.
The three-syndrome model of schizophrenic phenomenology has been well established in chronic illness. We report an attempt to replicate this concept in a sample of acutely unwell schizophrenic patients. Factor analysis was performed using PSE data collected within a week of admission from 114 patients who met DSMIII(R) diagnostic criteria for schizophrenia. Four main factors accounted for 58% of the variance. The first two factors closely resembled Liddle's disorganisation and psychomotor poverty syndromes. Hallucinations and delusions loaded separately under the third and fourth factors. To examine the validity of these four syndromes, the relationships between factor scores and other clinical data were examined. The disorganisation syndrome was associated with a history of multiple past admissions and a longer lifetime duration of in-patient treatment.
精神分裂症现象学的三综合征模型在慢性病中已得到充分确立。我们报告了一项在急性发病的精神分裂症患者样本中复制这一概念的尝试。使用从114名符合DSMIII(R)精神分裂症诊断标准的患者入院一周内收集的PSE数据进行了因子分析。四个主要因子解释了58%的方差。前两个因子与利德尔的紊乱和精神运动性贫困综合征非常相似。幻觉和妄想分别加载在第三和第四个因子下。为了检验这四种综合征的有效性，研究了因子得分与其他临床数据之间的关系。紊乱综合征与多次既往住院史和更长的终身住院治疗时间有关。
