Czernicki Z, Suzuki R, Nakagawa K, Hirakawa K, Endo S
Department of Neurosurgery, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Acta Neurochir (Wien). 1996;138(1):81-3. doi: 10.1007/BF01411729.
The effect of acetazolamide on the cerebral blood flow was studied in gerbils with unilateral carotid ligation. According to the effect of ligation the animals were divided into three groups: first group-the reduction more than 70%, second-CBF reduction 30-70% and the third group-CBF reduction less than 30%. The effect of acetazolamide administration was closely related to the effect of carotid ligation. More reduction of CBF was produced by carotid ligation, less increase of CBF after acetazolamide injection was noticed. The acetazolamide vascular reserve test was found a sensitive and useful method for detecting even modest reduction of vascular reserve in animals with slight - less than 30% CBF decrease following carotid ligation.
在单侧颈动脉结扎的沙鼠中研究了乙酰唑胺对脑血流量的影响。根据结扎效果将动物分为三组：第一组——血流量减少超过70%，第二组——脑血流量减少30 - 70%，第三组——脑血流量减少小于30%。乙酰唑胺给药的效果与颈动脉结扎的效果密切相关。颈动脉结扎导致脑血流量减少更多，注射乙酰唑胺后脑血流量增加较少。发现乙酰唑胺血管储备试验是一种灵敏且有用的方法，可用于检测颈动脉结扎后脑血流量轻微减少（小于30%）的动物中即使适度的血管储备减少情况。
