Lum L C, Thong M K, Cheah Y K, Lam S K
Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.
Ann Trop Paediatr. 1995 Dec;15(4):335-9. doi: 10.1080/02724936.1995.11747794.
In dengue shock syndrome, an acute increase in capillary permeability results in leakage of plasma into the interstitial space. Pleural effusion is commonly seen in dengue shock syndrome. We report three cases of dengue-associated adult respiratory distress syndrome (ARDS) in children, in all of whom dengue haemorrhagic fever, presenting with grade 3 or grade 4 dengue shock syndrome with disseminated intravascular coagulopathy, was confirmed. The criteria for the diagnosis of ARDS were based on the expanded definition of ARDS by Murray et al. Treatment consisted of fluid resuscitation, correction of coagulopathy and mechanical ventilation. All three children had multi-organ impairment, but it was more severe in the two who died. The one survivor was well at discharge.
在登革热休克综合征中，毛细血管通透性急性增加导致血浆渗漏到组织间隙。胸腔积液在登革热休克综合征中很常见。我们报告了3例儿童登革热相关的成人呼吸窘迫综合征（ARDS），所有患儿均确诊为登革出血热，表现为3级或4级登革热休克综合征并伴有弥散性血管内凝血。ARDS的诊断标准基于Murray等人对ARDS的扩展定义。治疗包括液体复苏、纠正凝血病和机械通气。所有3名儿童均有多器官损害，但在死亡的2名儿童中损害更为严重。1名幸存者出院时情况良好。
