Baur A, Stäbler A, Bartl R, Lamerz R, Reiser M
Institut für Radiologische Diagnostik, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
Rofo. 1996 Jun;164(6):457-63. doi: 10.1055/s-2007-1015689.
To define the different infiltration patterns in the spine in multiple myeloma, in correlation with histological and clinical findings. Quantitative signal evaluation with contrast media (Gd-DTPA). To compare the results in MRI with X-ray films.
61 patients with proven multiple myeloma and 50 controls were examined (1.0 Tesla, T1-w SE, opposed phase GE images).
Five infiltration patterns with different clinical stages were detected: normal bone marrow (11%) in cases of low interstitial marrow infiltration (biopsy), pure diffuse infiltration (25%), focal involvement (33%), combined diffuse/focal infiltration (23%) and a "salt-and pepper" pattern (8%). In diffuse plasmacytoma the 40% signal intensity increase was modification of diffuse infiltration. MRI proved to be more sensitive than radiography.
MRI is able to show the type and the extension of bone marrow infiltration in multiple myeloma. Diffuse involvement can be objective with gadopentetate dimeglumine.
明确多发性骨髓瘤脊柱的不同浸润模式，并与组织学和临床结果相关联。使用造影剂（钆喷酸葡胺）进行定量信号评估。比较MRI与X线片的结果。
对61例确诊为多发性骨髓瘤的患者和50例对照者进行检查（1.0特斯拉，T1加权自旋回波序列，反相位梯度回波图像）。
检测到五种不同临床分期的浸润模式：间质骨髓浸润程度低（活检）的病例中骨髓正常（11%）、单纯弥漫性浸润（25%）、局灶性受累（33%）、弥漫性/局灶性混合浸润（23%）和“椒盐”样模式（8%）。在弥漫性浆细胞瘤中，40%的信号强度增加是弥漫性浸润的改变。MRI被证明比放射照相更敏感。
MRI能够显示多发性骨髓瘤骨髓浸润的类型和范围。使用钆喷酸葡胺可客观显示弥漫性受累情况。
