Constans J, Viau M
Am J Hum Genet. 1977 May;29(3):280-6.
This study has analyzed the haptoglobin genotype frequencies in over 900 samples from populations living on the Northern slopes of the Pyrenees. The results emphasize the importance of systematically determining the frequencies of the Hp1S, Hp1F, Hp2SS, Hp2FF, Hp2FS alleles. Hp1S was the predominant allele, the HpIS/Hp1 distribution varying between .5 and .69 as in most European populations. Hp2 alleles were observed in low frequency with differences in geographically distinct samples. Pyrenean populations in the western zones (Basques and Baronnies) were found to contain the Hp2FF allele while those in eastern regions, the Hp2SS allele. We have speculated that Hp2SS is as old as the Hp2FF, arising from southern Mediterranean areas, and suggest that Pyrenean groups have different origins.
本研究分析了来自比利牛斯山脉北坡居民的900多个样本中的触珠蛋白基因型频率。结果强调了系统确定Hp1S、Hp1F、Hp2SS、Hp2FF、Hp2FS等位基因频率的重要性。Hp1S是主要等位基因，HpIS/Hp1分布在0.5至0.69之间，与大多数欧洲人群相同。观察到Hp2等位基因频率较低，且地理上不同的样本存在差异。发现西部地区（巴斯克人和巴罗尼人）的比利牛斯人群体含有Hp2FF等位基因，而东部地区的人群体含有Hp2SS等位基因。我们推测Hp2SS与Hp2FF一样古老，起源于地中海南部地区，并表明比利牛斯人群体有不同的起源。
