1-N-亚氨基糖抑制剂（唾液酸酶B类似物，用于α-N-乙酰半乳糖胺酶和β-N-乙酰葡糖胺酶）的合成与活性
Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase.
作者信息
Nishimura Y, Satoh T, Kudo T, Kondo S, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
Bioorg Med Chem. 1996 Jan;4(1):91-6. doi: 10.1016/0968-0896(95)00166-2.
PMID:8689244
Abstract
N-Acetylgalactosamine-based 1-N-iminosugars, new types of glycosidase inhibitor have been synthesized by modeling on siastatin B, isolated from a Streptomyces culture. The analogues of siastatin B were proved to be potent inhibitors for alpha-N-acetylgalactosaminidase and/or beta-N-acetylglucosaminidase.
摘要
基于N-乙酰半乳糖胺的1-N-亚氨基糖，一类新型的糖苷酶抑制剂，是通过对从链霉菌培养物中分离得到的西他司丁B进行建模合成的。西他司丁B的类似物被证明是α-N-乙酰半乳糖胺酶和/或β-N-乙酰葡糖胺酶的有效抑制剂。
Zotero 插件