来自红斑狼疮抗核抗体阳性血清的人免疫球蛋白G被动转移至小鼠后的命运

Fate of human IgG from lupus erythematosus antinuclear antibody positive sera passively transfered to mice.

作者信息

Herrera-Esparza R, Guzman-Enriquez L, Avalos-Diaz E

机构信息

Department of Immunology, Zacatecas University, Mexico.

出版信息

Rev Rhum Engl Ed. 1996 Feb;63(2):111-8.

PMID:8689281

Abstract

An animal model to study the fate of antinuclear antibodies (ANA) in vivo is reported. Newborn Balb/c mice were passively transferred by injection with sera from patients with autoimmune disease. The following antinuclear antibodies were found in the liver, spleen, kidneys and skin shortly after the injection: anti-dsDNA, nRNP, Ro/SSA and La/SSB. Clearance of all these antibodies occurred within 48 hours. The cytoskeleton, Fc immunoglobulin domain and Fc immunoglobulin-cell surface interaction may play a major role in the entry of antinuclear antibodies into cells, which may occur via endocytosis. Our animal model may be useful for studying the kinetics of binding of antinuclear antibodies to nuclear components and the effects of such binding in vivo.

摘要

本文报道了一种用于研究抗核抗体（ANA）在体内命运的动物模型。通过注射来自自身免疫性疾病患者的血清，将其被动转移至新生的Balb/c小鼠体内。注射后不久，在肝脏、脾脏、肾脏和皮肤中发现了以下抗核抗体：抗双链DNA、核核糖核蛋白、Ro/SSA和La/SSB。所有这些抗体在48小时内清除。细胞骨架、Fc免疫球蛋白结构域和Fc免疫球蛋白与细胞表面的相互作用可能在抗核抗体进入细胞的过程中起主要作用，这一过程可能通过内吞作用发生。我们的动物模型可能有助于研究抗核抗体与核成分结合的动力学以及这种结合在体内的影响。