转化生长因子β1和转化生长因子β2对组织培养中人类眼球筋膜囊成纤维细胞增殖的影响。
The effect of TGF-beta 1 and TGF-beta 2 on the proliferation of human Tenon's capsule fibroblasts in tissue culture.
作者信息
Cunliffe I A, Rees R C, Rennie I G
机构信息
Department of Ophthalmology and Orthoptics, Royal Hallamshire Hospital, Sheffield, UK.
出版信息
Acta Ophthalmol Scand. 1996 Feb;74(1):31-5. doi: 10.1111/j.1600-0420.1996.tb00677.x.
This study examines the effect of transforming growth factor beta 1 and 2 (TGF-beta 1 and TGF-beta 2) on the proliferation of human Tenon's capsule fibroblasts in tissue culture. Both TGF-beta 1 and TGF-beta 2 were shown to stimulate proliferation at 1000 and 100 pg/ml concentrations. We discuss the significance of these findings with respect to wound healing following trabeculectomy, and postulate why some eyes are more at risk of failure than others.
本研究检测了转化生长因子β1和β2（TGF-β1和TGF-β2）对组织培养中人类眼球筋膜囊成纤维细胞增殖的影响。结果显示，TGF-β1和TGF-β2在浓度为1000 pg/ml和100 pg/ml时均能刺激细胞增殖。我们讨论了这些发现对于小梁切除术后伤口愈合的意义，并推测为何有些眼睛比其他眼睛更易出现手术失败的风险。
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