Cunliffe I, McIntyre C, Rees R, Rennie I
Department of Ophthalmology and Orthoptics, Royal Hallamshire Hospital, Sheffield, UK.
Ger J Ophthalmol. 1995 May;4(3):167-74.
Several recent publications have suggested that the long-term use of topical antiglaucoma medications may be detrimental to the outcome of trabeculectomy. In this study we investigated the effect of topical beta-blocker medications on the proliferation and viability of human Tenon's capsule fibroblasts in tissue culture to see if there was a direct mechanism of enhanced proliferation. None of the tested medications stimulated the proliferation of fibroblasts. They were shown to have an inhibitory effect on proliferation and were toxic to cells at higher concentrations. The relevance of these findings to wound healing following trabeculectomy is discussed.
最近的几篇出版物表明，长期使用局部抗青光眼药物可能对小梁切除术的结果不利。在本研究中，我们在组织培养中研究了局部β受体阻滞剂药物对人Tenon囊成纤维细胞增殖和活力的影响，以观察是否存在增殖增强的直接机制。所测试的药物均未刺激成纤维细胞的增殖。它们显示出对增殖有抑制作用，并且在较高浓度下对细胞有毒性。讨论了这些发现与小梁切除术后伤口愈合的相关性。
