Noda N, Tanaka R, Miyahara K, Sukamoto T
Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Chem Pharm Bull (Tokyo). 1996 May;44(5):895-9. doi: 10.1248/cpb.44.895.
Six neutral glycosphingolipids were isolated in the pure state from the leech, Hirudo nipponica (Annelida). In contrast to the zwitterionic monogalactosylceramides carrying a choline phosphate group so far obtained, all compounds are non-zwitterionic glycosphingolipids, trigalactosylceramides. Five compounds possess a Ga1 alpha 1-6Ga1 alpha 1-6Ga1 beta 1-Cer core, and one is unique in having a Ga1 alpha 1-6Ga1 beta 1-Cer structure. Their full structures have been determined on the bases of chemical and spectral evidence.
从日本医蛭（环节动物门）中分离出六种呈纯态的中性糖鞘脂。与迄今所获得的带有磷酸胆碱基团的两性离子单半乳糖基神经酰胺不同，所有化合物均为非两性离子糖鞘脂——三半乳糖基神经酰胺。五种化合物具有Galα1-6Galα1-6Galβ1-Cer核心结构，另一种则独特地具有Galα1-6Galβ1-Cer结构。基于化学和光谱证据确定了它们的完整结构。
