Mills P J, Ziegler M G, Nelesen R A, Kennedy B P
Department of Psychiatry, UCSD Medical Center, University of California 92103-0804, USA.
Clin Pharmacol Ther. 1996 Jul;60(1):99-104. doi: 10.1016/S0009-9236(96)90172-1.
To examine possible effects of race, sex, and the menstrual cycle on adrenergic receptors (beta 2 and alpha 2) and agonists.
Sixty-three normotensive black men and women and white men and women were studied twice, approximately 6 weeks apart. Women were studied once during the follicular phase and once during the luteal phase of the menstrual cycle. beta 2-Adrenergic receptors and adenylate cyclase activity were examined on lymphocytes, and alpha 2-adrenergic receptors were examined on platelets. Norepinephrine and epinephrine were determined in plasma.
Women showed greater lymphocyte beta 2-receptor sensitivity (isoproterenol-stimulated cyclic adenosine monophosphate; p = 0.009). Women also showed greater postreceptor adenylate cycle activity independent of the beta-receptor (forskolin stimulation; p = 0.006). When these differences were controlled for, the gender-related differences in beta 2-receptor sensitivity were no longer evident. Black women had a reduced beta 2-receptor sensitivity in the luteal phase compared with the follicular phase, whereas white women showed no significant change (p = 0.018). Black subjects had lower lymphocyte beta 2-receptor density (Bmax) values than white subjects (p = 0.047). There were no significant effects on alpha 2-adrenergic receptors.
The findings suggest that although there is no generalized effect of the menstrual cycle on adrenergic receptors in white women, such an effect may occur in black women. The findings also suggest that previously reported gender-related differences in beta 2-receptor sensitivity may be due to gender-related differences in postreceptor activity and not the beta 2-receptor per se.
研究种族、性别和月经周期对肾上腺素能受体（β2和α2）及激动剂的可能影响。
对63名血压正常的黑人男性和女性以及白人男性和女性进行了两次研究，两次研究间隔约6周。女性在月经周期的卵泡期和黄体期各进行一次研究。检测淋巴细胞上的β2肾上腺素能受体和腺苷酸环化酶活性，以及血小板上的α2肾上腺素能受体。测定血浆中的去甲肾上腺素和肾上腺素。
女性表现出更高的淋巴细胞β2受体敏感性（异丙肾上腺素刺激的环磷酸腺苷；p = 0.009）。女性还表现出独立于β受体的更高的受体后腺苷酸环化酶活性（福斯高林刺激；p = 0.006）。当控制这些差异后，β2受体敏感性的性别相关差异不再明显。与卵泡期相比，黑人女性在黄体期的β2受体敏感性降低，而白人女性无显著变化（p = 0.018）。黑人受试者的淋巴细胞β2受体密度（Bmax）值低于白人受试者（p = 0.047）。对α2肾上腺素能受体无显著影响。
研究结果表明，虽然月经周期对白人女性的肾上腺素能受体没有普遍影响，但对黑人女性可能有这种影响。研究结果还表明，先前报道的β2受体敏感性的性别相关差异可能是由于受体后活性的性别相关差异，而非β2受体本身。
