Mills P J, Dimsdale J E, Ziegler M G, Nelesen R A
University of California at San Diego Medical Center 92103-0804.
Hypertension. 1995 Jan;25(1):88-91. doi: 10.1161/01.hyp.25.1.88.
This study examined the effects of ethnicity and hypertension on beta 2-adrenergic receptors and on plasma catecholamines in a group of 77 unmedicated mildly hypertensive and normotensive men. Black hypertensive subjects had the most sensitive and white hypertensive subjects the least sensitive beta-receptors (as assessed by isoproterenol-stimulated cyclic AMP in lymphocytes [P = .02]). In contrast, postreceptor adenylate cyclase activation (as assessed by forskolin stimulation) was similar among groups. As with beta-receptor sensitivity, black hypertensive subjects had the highest beta-receptor density and white hypertensive subjects the lowest (P = .03). Blacks demonstrated lower plasma epinephrine values compared with whites (P = .03). Across all subjects, plasma epinephrine was negatively correlated with beta-receptor density (r = -.26, P < .05) and sensitivity (r = -.25, P < .05). There were no group differences in binding affinity to the beta-antagonist iodopindolol. The findings support the notion of increased beta-adrenergic receptors in hypertension in blacks.
本研究在一组77名未接受药物治疗的轻度高血压和血压正常男性中，考察了种族和高血压对β2-肾上腺素能受体以及血浆儿茶酚胺的影响。黑人高血压受试者的β受体最敏感，而白人高血压受试者的β受体最不敏感（通过淋巴细胞中异丙肾上腺素刺激的环磷酸腺苷评估[P = .02]）。相比之下，各组之间受体后腺苷酸环化酶的激活（通过福斯高林刺激评估）相似。与β受体敏感性一样，黑人高血压受试者的β受体密度最高，白人高血压受试者的β受体密度最低（P = .03）。与白人相比，黑人的血浆肾上腺素值较低（P = .03）。在所有受试者中，血浆肾上腺素与β受体密度呈负相关（r = -.26，P < .05），与敏感性也呈负相关（r = -.25，P < .05）。各组对β拮抗剂碘吲哚洛尔的结合亲和力没有差异。这些发现支持了黑人高血压患者β-肾上腺素能受体增加的观点。
