锰-二乙烯三胺五乙酸增强磁共振肝脏成像：脉冲序列性能分析

Mn-DPDP enhanced MR imaging of the liver: analysis of pulse sequence performance.

作者信息

Slater G J, Saini S, Mayo-smith W W, Sharma P, Eisenberg P J, Hahn P F

机构信息

Department of Radiology, Massachusetts General Hospital, Boston, USA.

出版信息

Clin Radiol. 1996 Jul;51(7):484-6. doi: 10.1016/s0009-9260(96)80187-5.

DOI:10.1016/s0009-9260(96)80187-5

PMID:8689823

Abstract

AIM

To compare liver enhancement and lesion-liver contrast on T1-weighted (T1W) gradient recalled echo (GRE), spin-echo (SE) and fat-suppressed SE (FS-SE) pulse sequences at Manganese-DPDP (Mn-DPDP) enhanced magnetic resonance (MR) imaging of the liver. PATIENTS AND METHODS. Twenty-one patients with known liver lesions were administered 5 mumol/kg of Mn-DPDP. TIW GRE (78/2.3/80 degrees), SE and F-SE (300/12) images were obtained before and 15 min after Mn-DPDP. Signal/noise ratio (SNR) and lesion-liver contrast/noise ratio (CNR) were calculated for each pulse sequence.

RESULTS

Liver SNR (n = 21) and lesion-liver CNR (n = 10) increased significantly after Mn-DPDP on all three pulse sequences (P < 0.0001). Liver SNR was highest on the FS-SE and GRE pulse sequences (FS-SE = 43.8, GRE = 38.4, SE = 29.2). Lesion-liver CNR was highest on the FS-SE pulse sequence (FS-SE = -29.3, SE = -23.2, GRE = -19.8), which was significantly higher than the GRE pulse sequence (P < 0.05).

CONCLUSION

The T1-weighted fat-suppressed SE (FS-SE) pulse sequence provides highest liver enhancement and lesion-liver contrast and is recommended for Mn-DPDP enhanced MR imaging.

摘要

目的

在锰-二吡啶二硫代磷酸酯（Mn-DPDP）增强肝脏磁共振成像中，比较T1加权（T1W）梯度回波（GRE）、自旋回波（SE）和脂肪抑制SE（FS-SE）脉冲序列上肝脏强化及病变-肝脏对比情况。患者与方法。21例已知肝脏病变患者接受5 μmol/kg的Mn-DPDP。在注射Mn-DPDP前及注射后15分钟获取T1W GRE（78/2.3/80°）、SE和FS-SE（300/12）图像。计算每个脉冲序列的信噪比（SNR）及病变-肝脏对比噪声比（CNR）。

结果

在所有三个脉冲序列上，注射Mn-DPDP后肝脏SNR（n = 21）及病变-肝脏CNR（n = 10）均显著升高（P < 0.0001）。FS-SE和GRE脉冲序列上肝脏SNR最高（FS-SE = 43.8，GRE = 38.4，SE = 29.2）。FS-SE脉冲序列上病变-肝脏CNR最高（FS-SE = -29.3，SE = -23.2，GRE = -19.8），显著高于GRE脉冲序列（P < 0.05）。