Lim Joon Seok, Kim Myeong Jin, Jung Yong Yun, Kim Ki Whang
Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, Korea.
Korean J Radiol. 2005 Oct-Dec;6(4):229-34. doi: 10.3348/kjr.2005.6.4.229.
To compare the efficacy of Mangafodipir trisodium (Mn-DPDP)-enhanced MR cholangiogrphy (MRC) and Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRC in visualizing a non-dilated biliary system.
Eighty-eight healthy liver donor candidates underwent contrast-enhanced T1-weighted MRC. Mn-DPDP and Gd-BOPTA was used in 36 and 52 patients, respectively. Two radiologists reviewed the MR images and rated the visualization of the common duct, the right and left hepatic ducts, and the second-order branches using a 4-point scale. The contrast-to-noise ratio (CNR) of the common duct to the liver in the two groups was also compared.
Mn-DPDP MRC and Gd-BOPTA MRC both showed similar visualization grades in the common duct (p=.380, Mann-Whitney U test). In the case of the proximal bile ducts, the median visualization grade was significantly higher with Gd-BOPTA MRC than with Mn-DPDP MRC (right hepatic duct: p=0.016, left hepatic duct: p=0.014, right secondary order branches: p=0.006, left secondary order branches, p=0.003). The common duct-to-liver CNR of the Gd-BOPTA MRC group was significantly higher (38.90+/-24.50) than that of the Mn-DPDP MRC group (24.14+/-17.98) (p=.003, Student's t test).
Gd-BOPTA, as a biliary contrast agent, is a potential substitute for Mn-DPDP.
比较锰福地匹三钠（Mn-DPDP）增强磁共振胰胆管造影（MRC）和钆贝葡胺（Gd-BOPTA）增强MRC对未扩张胆管系统的显影效果。
88名健康的肝脏供体候选人接受了对比增强T1加权MRC检查。分别有36例和52例患者使用了Mn-DPDP和Gd-BOPTA。两名放射科医生对MR图像进行了评估，并使用4分制对胆总管、左右肝管以及二级分支的显影情况进行评分。同时还比较了两组中胆总管与肝脏的对比噪声比（CNR）。
Mn-DPDP MRC和Gd-BOPTA MRC在胆总管的显影分级上相似（p = 0.380，曼-惠特尼U检验）。在近端胆管方面，Gd-BOPTA MRC的中位显影分级显著高于Mn-DPDP MRC（右肝管：p = 0.016，左肝管：p = 0.014，右二级分支：p = 0.006，左二级分支：p = 0.003）。Gd-BOPTA MRC组的胆总管与肝脏CNR显著高于Mn-DPDP MRC组（38.90±24.50）（24.14±17.98）（p = 0.003，学生t检验）。
Gd-BOPTA作为一种胆管造影剂，是Mn-DPDP的潜在替代品。
