蝇蕈醇对吗啡依赖小鼠中纳洛酮诱发的戒断症状的影响
Modification by muscimol of naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
作者信息
El-Kadi A O, Sharif S I
机构信息
Department of Pharmacology, Al-Arab Medical University, Benghazi, Libya.
出版信息
Gen Pharmacol. 1995 Nov;26(7):1579-81. doi: 10.1016/0306-3623(95)00053-4.
PMID:8690249
Abstract
- In morphine-dependent mice, muscimol, a GABAA agonist when given i.p. 30 min before naloxone, attenuated the naloxone-precipitated withdrawal symptoms of jumping, "wet dog" shakes and burrowing, but not body weight loss. 2. Muscimol produced a hypothermic effect which was further aggravated by naloxone.
摘要
- 在吗啡依赖的小鼠中，在纳洛酮给药前30分钟腹腔注射GABAA激动剂蝇蕈醇，可减轻纳洛酮诱发的跳跃、“湿狗”样抖动和挖掘等戒断症状，但不能减轻体重减轻。2. 蝇蕈醇产生体温过低效应，纳洛酮会使其进一步加重。
Zotero 插件