白细胞介素-7受体α对γδ + T细胞的发育至关重要，但对自然杀伤细胞的发育并非如此。
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
作者信息
He Y W, Malek T R
机构信息
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA.
出版信息
J Exp Med. 1996 Jul 1;184(1):289-93. doi: 10.1084/jem.184.1.289.
Abstract
Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells.
摘要
缺乏白细胞介素（IL）-2、IL-4、IL-7、IL-9和IL-15受体功能性γc亚基的小鼠在淋巴细胞发育方面表现出严重缺陷。IL-7/IL-7R系统是传统T细胞和B细胞发育的关键相互作用。在本报告中，研究了IL-7Rα在传统T细胞和B细胞以外的淋巴细胞谱系发育中的作用。我们证明，IL-7Rα缺陷小鼠中不存在γδ + T细胞，而自然杀伤细胞的发育和功能正常。因此，γδ + T细胞的发育需要IL-7Rα功能，但自然杀伤细胞不需要。
相似文献
1
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.白细胞介素-7受体α对γδ + T细胞的发育至关重要，但对自然杀伤细胞的发育并非如此。
J Exp Med. 1996 Jul 1;184(1):289-93. doi: 10.1084/jem.184.1.289.
2
Interleukin 7 receptor-deficient mice lack gammadelta T cells.白细胞介素7受体缺陷型小鼠缺乏γδT细胞。
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7172-7. doi: 10.1073/pnas.93.14.7172.
3
An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state.用于肠道上皮内T细胞发育的白细胞介素-7网络：配体或受体敲除揭示免疫缺陷状态的差异。
Eur J Immunol. 1997 Sep;27(9):2133-8. doi: 10.1002/eji.1830270903.
4
The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells.白细胞介素-7在T细胞受体γδ细胞胸腺内及胸腺外发育中的作用
J Immunol. 1998 Jul 15;161(2):707-13.
5
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.白细胞介素-15和白细胞介素-2对双潜能T/自然杀伤祖细胞分化的不同作用。
J Exp Med. 1996 Aug 1;184(2):325-36. doi: 10.1084/jem.184.2.325.
6
Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes.白细胞介素2（IL-2）和白细胞介素7（IL-7）相互诱导γδT细胞受体阳性上皮内淋巴细胞上的IL-7和IL-2受体。
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3613-8. doi: 10.1073/pnas.93.8.3613.
7
The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.细胞因子受体的共同γ链在多个阶段调节胸腺内T细胞的发育。
J Immunol. 1997 Mar 15;158(6):2592-9.
8
Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice.CD3ζ缺陷小鼠中NK1.1⁺ T细胞抗原受体（TCR）α/β⁺ T细胞的发育停滞以及NK1.1⁺ TCRγ/δ⁺ T细胞发育的扩增。
J Exp Med. 1995 Sep 1;182(3):891-5. doi: 10.1084/jem.182.3.891.
9
Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules.自然杀伤（NK）T细胞的谱系关系与分化：在缺乏NKR-P1和Ly49分子的情况下胸腺内选择及白细胞介素（IL）-4的产生
J Exp Med. 1997 Apr 21;185(8):1395-401. doi: 10.1084/jem.185.8.1395.
10
Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice.T细胞因子-1缺陷小鼠中肠道T细胞受体γδ⁺细胞和肝脏CD4⁺NK1⁺T细胞受体αβ⁺细胞的发育选择性受损。
Eur J Immunol. 1996 Feb;26(2):351-5. doi: 10.1002/eji.1830260213.
引用本文的文献
1
IL-7 in autoimmune diseases: mechanisms and therapeutic potential.白细胞介素-7在自身免疫性疾病中的作用机制及治疗潜力
Front Immunol. 2025 Apr 17;16:1545760. doi: 10.3389/fimmu.2025.1545760. eCollection 2025.
2
Uncovering the mysteries of human gamma delta T cells: from origins to novel therapeutics.揭开人类γδT细胞的奥秘：从起源到新型疗法。
Front Immunol. 2025 Apr 10;16:1543454. doi: 10.3389/fimmu.2025.1543454. eCollection 2025.
3
Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency.Janus激酶3（JAK3）：免疫中的关键保守节点，在免疫细胞癌症和免疫缺陷中被破坏。
Int J Mol Sci. 2024 Mar 4;25(5):2977. doi: 10.3390/ijms25052977.
4
Inflammatory-driven NK cell maturation and its impact on pathology.炎症驱动的 NK 细胞成熟及其对病理学的影响。
Front Immunol. 2022 Dec 9;13:1061959. doi: 10.3389/fimmu.2022.1061959. eCollection 2022.
5
Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation.斑马鱼 JAK3 基因突变所致严重联合免疫缺陷（SCID）模型。
Biomolecules. 2022 Oct 20;12(10):1521. doi: 10.3390/biom12101521.
6
Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis.白细胞介素-7 生物学及其对免疫细胞的影响：生成、分化、存活和稳态的介质。
Front Immunol. 2021 Dec 2;12:747324. doi: 10.3389/fimmu.2021.747324. eCollection 2021.
7
Molecular Regulation of NK Cell Maturation.自然杀伤细胞成熟的分子调控。
Front Immunol. 2020 Aug 11;11:1945. doi: 10.3389/fimmu.2020.01945. eCollection 2020.
8
Regulation of γδ T Cell Effector Diversification in the Thymus.γδ T 细胞效应分化在胸腺中的调控。
Front Immunol. 2020 Jan 24;11:42. doi: 10.3389/fimmu.2020.00042. eCollection 2020.
9
Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview.多发性硬化症患者的遗传与分子生物学：综述。
Cell Mol Neurobiol. 2020 Jan;40(1):65-85. doi: 10.1007/s10571-019-00731-2. Epub 2019 Sep 3.
10
Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With Mutation.突变患者 T 细胞 repertoire 功能和多样性降低，且临床病程不同。
Front Immunol. 2019 Jul 17;10:1672. doi: 10.3389/fimmu.2019.01672. eCollection 2019.
本文引用的文献
1
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.
J Immunol. 1996 Feb 1;156(3):1117-25.
2
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.白细胞介素-2受体γ链突变导致人类X连锁重症联合免疫缺陷。
Cell. 1993 Apr 9;73(1):147-57. doi: 10.1016/0092-8674(93)90167-o.
3
Expression and function of the interleukin 7 receptor in murine lymphocytes.白细胞介素7受体在小鼠淋巴细胞中的表达与功能
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9125-9. doi: 10.1073/pnas.90.19.9125.
4
Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.抗白细胞介素7单克隆抗体对小鼠体内B淋巴细胞和T淋巴细胞生成的抑制作用。
J Exp Med. 1993 Jul 1;178(1):257-64. doi: 10.1084/jem.178.1.257.
5
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.白细胞介素-2受体γ链：白细胞介素-4受体的功能组分。
Science. 1993 Dec 17;262(5141):1880-3. doi: 10.1126/science.8266078.
6
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.白细胞介素-2受体γ链：白细胞介素-7受体的功能成分。
Science. 1993 Dec 17;262(5141):1877-80. doi: 10.1126/science.8266077.
7
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.白细胞介素-2（IL-2）受体γ链在IL-2和IL-4受体之间的共用。
Science. 1993 Dec 17;262(5141):1874-7. doi: 10.1126/science.8266076.
8
Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice.角质形成细胞衍生的白细胞介素-7作为小鼠树突状表皮T细胞的生长因子。
J Immunol. 1993 Dec 1;151(11):6012-9.
9
Immune responses in interleukin-2-deficient mice.白细胞介素-2缺陷小鼠的免疫反应。
Science. 1993 Nov 12;262(5136):1059-61. doi: 10.1126/science.8235625.
10
Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.白细胞介素-2受体γ链在白细胞介素-7受体复合物中的功能参与。
Science. 1994 Mar 11;263(5152):1453-4. doi: 10.1126/science.8128231.
Zotero 插件