He Y W, Malek T R
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA.
J Exp Med. 1996 Jul 1;184(1):289-93. doi: 10.1084/jem.184.1.289.
Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells.
缺乏白细胞介素(IL)-2、IL-4、IL-7、IL-9和IL-15受体功能性γc亚基的小鼠在淋巴细胞发育方面表现出严重缺陷。IL-7/IL-7R系统是传统T细胞和B细胞发育的关键相互作用。在本报告中,研究了IL-7Rα在传统T细胞和B细胞以外的淋巴细胞谱系发育中的作用。我们证明,IL-7Rα缺陷小鼠中不存在γδ + T细胞,而自然杀伤细胞的发育和功能正常。因此,γδ + T细胞的发育需要IL-7Rα功能,但自然杀伤细胞不需要。