白细胞介素-2受体γ链在白细胞介素-7受体复合物中的功能参与。

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.

作者信息

Kondo M, Takeshita T, Higuchi M, Nakamura M, Sudo T, Nishikawa S, Sugamura K

机构信息

Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Science. 1994 Mar 11;263(5152):1453-4. doi: 10.1126/science.8128231.

DOI:10.1126/science.8128231

PMID:8128231

Abstract

The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.

摘要

白细胞介素-2（IL-2）受体的γ链与功能性IL-4受体共有，且与X连锁重症联合免疫缺陷病（XSCID）存在因果关系，该病归因于严重的T细胞缺陷。针对IL-2受体γ链的单克隆抗体研究表明，γ链参与了IL-7的功能性高亲和力受体复合物，该复合物与T细胞和B细胞的分化有关。γ亚基参与多种受体可能有助于阐明XSCID的发病机制和淋巴细胞分化机制。