Biały Sylwia, Bogunia-Kubik Katarzyna
Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Front Immunol. 2025 Apr 10;16:1543454. doi: 10.3389/fimmu.2025.1543454. eCollection 2025.
Gamma delta (γδ) T cells represent a unique and distinct population of lymphocytes that bridge the innate and adaptive immune responses. This functional duality positions them as one of the pivotal elements in the evolution and development of the human body's defense mechanisms. This review aims to provide a comprehensive and in-depth overview of γδ T cells, covering their origins, development, classification, and functional roles in immunology. Special attention is given to their involvement in the pathogenesis of autoimmune and cancer-related diseases-areas that remain subjects of intensive research with many unanswered questions. Additionally, this article explores the therapeutic potential of γδ T cells, which hold promise as a novel approach to treating various difficult-to-manage diseases. The review also presents an analysis of the latest clinical studies utilizing γδ T cells, emphasizing their emerging role in modern medicine. The ultimate goal of this work is to offer a holistic perspective on the current state of research on γδ T cells and their prospective applications in immunotherapy and cancer treatment, highlighting their potential to become a groundbreaking tool in future medical interventions.
γδ T细胞是一类独特且与众不同的淋巴细胞群体，它们在固有免疫和适应性免疫反应之间架起了桥梁。这种功能上的双重性使它们成为人体防御机制进化和发展的关键要素之一。本综述旨在全面深入地概述γδ T细胞，涵盖其起源、发育、分类以及在免疫学中的功能作用。特别关注它们在自身免疫性疾病和癌症相关疾病发病机制中的作用——这些领域仍是深入研究的对象，存在许多未解决的问题。此外，本文探讨了γδ T细胞的治疗潜力，它们有望成为治疗各种难治性疾病的新方法。该综述还对利用γδ T细胞的最新临床研究进行了分析，强调了它们在现代医学中日益凸显的作用。这项工作的最终目标是全面呈现γδ T细胞的当前研究状况及其在免疫治疗和癌症治疗中的潜在应用，突出它们未来有可能成为医学干预中开创性工具的潜力。
