Erickson K L, Beutler J A, Gray G N, Cardellina J H, Boyd M R
Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
J Nat Prod. 1995 Dec;58(12):1848-60. doi: 10.1021/np50126a007.
Seven new sesquiterpenes, majapolenes A [1] and B [2], majapolone [3], and majapols A [4], B [5], C [6], and D [7], were isolated from a Philippine collection of Laurencia majuscula. With the exception of majapolene B [2], all compounds were isolated as inseparable diastereomeric mixtures. Structure elucidation was achieved by spectroscopic methods. Majapolene A [1], a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of Laurencia caraibica.
从菲律宾采集的大团扇藻（Laurencia majuscula）中分离出了七种新的倍半萜，即马贾波烯A [1]和B [2]、马贾波酮[3]以及马贾波醇A [4]、B [5]、C [6]和D [7]。除马贾波烯B [2]外，所有化合物均以不可分离的非对映异构体混合物形式被分离出来。通过光谱方法完成了结构解析。二氧杂双环[2.2.2] - 烯烃马贾波烯A [1]在NCI 60细胞系细胞毒性筛选中表现出适度的活性。马贾波烯A也是菲律宾采集的加勒比海团扇藻（Laurencia caraibica）中的主要成分。
