佩斯勒菌素A和B：来自软珊瑚佩斯勒软珊瑚的新型三环倍半萜类化合物。

Paesslerins A and B: novel tricyclic sesquiterpenoids from the soft coral Alcyonium paessleri.

作者信息

Rodríguez Brasco M F, Seldes A M, Palermo J A

机构信息

Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pab. 2, (1428) Buenos Aires, Argentina.

出版信息

Org Lett. 2001 May 17;3(10):1415-7. doi: 10.1021/ol006684x.

DOI:10.1021/ol006684x

PMID:11388830

Abstract

[structure: see text] In the course of our search of new bioactive metabolites from marine invertebrates, paesslerins A and B, sesquiterpenoids with an unprecedented tricyclic skeleton, were isolated from the subAntarctic soft coral Alcyonium paessleri collected at a depth of 200 m near the South Georgia islands, and their structures were elucidated by spectroscopic techniques. These compounds show moderate cytotoxicity in preliminary assays.

摘要

[结构：见正文] 在我们从海洋无脊椎动物中寻找新的生物活性代谢物的过程中，从南乔治亚岛附近200米深处采集的亚南极软珊瑚Alcyonium paessleri中分离出了具有前所未有的三环骨架的倍半萜类化合物派斯勒菌素A和B，并通过光谱技术阐明了它们的结构。这些化合物在初步试验中显示出中等的细胞毒性。