Ohta H, Watanabe H, Sawabu N
Department of Internal Medicine, Tonami General Hospital, Kanazawa University.
Nihon Rinsho. 1996 Jun;54(6):1505-9.
Expression of cancerous isoenzymes in various malignant tumors has been extensively studied using different biochemical techniques. Cancerous alkaline phosphatase (ALP) isoenzymes, such as placental ALP and variant ALP, are detected from sera of patients with various malignant diseases. Variant ALP is a specific tumor marker for hepatocellular carcinoma (HCC). The positive rate of each ALP isoenzyme is, however, low except for a high positivity of placental ALP in seminoma. Novel gamma-glutamyltranspeptidase (gamma-GTP) isoenzyme is specifically found in about 60% of the sera from patients with HCC but in only 3% of those from patients with benign liver diseases, suggesting a high specificity for HCC. Thus, cancerous isoenzymes are available for diagnosis of various malignant tumors.
利用不同的生化技术，对各种恶性肿瘤中癌同工酶的表达进行了广泛研究。癌性碱性磷酸酶（ALP）同工酶，如胎盘碱性磷酸酶和变异型碱性磷酸酶，可在患有各种恶性疾病患者的血清中检测到。变异型碱性磷酸酶是肝细胞癌（HCC）的一种特异性肿瘤标志物。然而，除精原细胞瘤中胎盘碱性磷酸酶阳性率较高外，每种碱性磷酸酶同工酶的阳性率都较低。新型γ-谷氨酰转肽酶（γ-GTP）同工酶在约60%的肝癌患者血清中特异性发现，但在良性肝病患者血清中仅为3%，提示其对肝癌具有高度特异性。因此，癌同工酶可用于各种恶性肿瘤的诊断。
