Nakamura F, Kaimori M, Takaya H, Fujita K, Suzuki N, Sakurabayashi I, Yoshioka N
Department of Clinical Laboratory, Aomori Prefectural Central Hospital, Japan.
Rinsho Byori. 1996 Jan;44(1):85-9.
We reported a non-diabetic patient with IgA-kappa multiple myeloma whose serum fructosamine value was markedly elevated. The M-protein from this patient was shown to be conjugated to serum albumin confirmed by immunoelectrophoresis and immunofixation. The fructosamine activity was shown in the high molecular weight fraction by S-300 superfine gel chromatography. Although serum fructosamine values of other three non-diabetic patients with IgA type multiple myeloma were elevated, patients with IgG type multiple myeloma and primary macroglobulinemia had low or normal serum fructosamine values. These findings suggested that glycation of monoclonal IgA of multiple myeloma was much more increased than that of other types of immunoglobulins and monoclonal IgA in this patient was conjugated to serum albumin resulting in the elevated serum fructosamine.
我们报告了一例患有IgA-κ型多发性骨髓瘤的非糖尿病患者，其血清果糖胺值显著升高。通过免疫电泳和免疫固定法证实，该患者的M蛋白与血清白蛋白结合。经S-300超细凝胶色谱法检测，果糖胺活性存在于高分子量组分中。虽然其他三名IgA型多发性骨髓瘤非糖尿病患者的血清果糖胺值也升高，但IgG型多发性骨髓瘤和原发性巨球蛋白血症患者的血清果糖胺值较低或正常。这些发现表明，多发性骨髓瘤的单克隆IgA糖基化程度比其他类型免疫球蛋白的糖基化程度增加得更多，且该患者的单克隆IgA与血清白蛋白结合，导致血清果糖胺升高。
