Kavanaugh M P, Kabat D
Vollum Institute, Oregon Health Sciences University, Portland, USA.
Kidney Int. 1996 Apr;49(4):959-63. doi: 10.1038/ki.1996.135.
The cell-surface receptors for gibbon ape leukemia virus (Glvr-1; [1]) and rat amphotropic virus (Ram-1; [2]) were recently demonstrated to serve normal cellular functions as sodium-dependent phosphate transporters [3, 4]. These transporters, called PiT-1 and PiT-2, respectively, are approximately 59% identical in amino acid sequence and are members of a gene family distinct from the renal type I and type II NaPi sodium-dependent phosphate transporters. Both PiT-1 and PiT-2 are widely distributed in many tissues including kidney, brain, heart, liver, muscle, and bone marrow. Expression of both transporters is increased by phosphate deprivation. The distinct structural and functional properties of these molecules establishes them as members of a new family of phosphate transporters which may play a major role in phosphate uptake in a wide variety of cell types.
长臂猿白血病病毒（Glvr-1；[1]）和大鼠嗜异性病毒（Ram-1；[2]）的细胞表面受体最近被证明作为钠依赖性磷酸盐转运体发挥正常细胞功能[3,4]。这些转运体分别称为PiT-1和PiT-2，氨基酸序列约59%相同，是一个不同于肾I型和II型NaPi钠依赖性磷酸盐转运体的基因家族成员。PiT-1和PiT-2均广泛分布于包括肾脏、大脑、心脏、肝脏、肌肉和骨髓在内的许多组织中。两种转运体的表达都因磷酸盐缺乏而增加。这些分子独特的结构和功能特性使其成为一个新的磷酸盐转运体家族成员，可能在多种细胞类型的磷酸盐摄取中起主要作用。
