Oka K, Yamamoto M, Nonaka T, Tomonaga M
Department of Neurosurgery, Fukuoka University School of Medicine, Japan.
Neurosurgery. 1996 Apr;38(4):733-6.
To compare the benefits of physiological saline solution and artificial cerebrospinal fluid (CSF) as perfusates, we investigated 12 patients with presumed symptomatic aqueductal stenosis by clinical course and CSF analysis. In all patients, endoneurosurgical third ventriculostomy and cine magnetic resonance imaging confirmed the patency of ventriculostomy. After endoneurosurgery, patients who received the saline solution experienced high fever, headaches, and elevated cell count in lumbar CSF. Saline solution provoked a striking inflammatory reaction in the CSF. In contrast, the artificial CSF reduced these conditions to a minimum. Artificial CSF used as a physiological perfusate during endoneurosurgery can suppress host reactions within the CSF pathway and is also available for routine neurosurgical procedures.
为比较生理盐水溶液和人工脑脊液作为灌注液的益处，我们通过临床病程和脑脊液分析，对12例推测为症状性导水管狭窄的患者进行了研究。所有患者均接受了神经内镜下第三脑室造瘘术，电影磁共振成像证实了造瘘口通畅。神经内镜手术后，接受生理盐水溶液灌注的患者出现高热、头痛，腰椎脑脊液中的细胞计数升高。生理盐水溶液在脑脊液中引发了显著的炎症反应。相比之下，人工脑脊液将这些情况降至最低。在神经内镜手术期间用作生理性灌注液的人工脑脊液可抑制脑脊液通路内的宿主反应，并且也可用于常规神经外科手术。
