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Lys-plasminogen as an adjunct to local intra-arterial fibrinolysis for carotid territory stroke: laboratory and clinical findings.

作者信息

Freitag H J, Becker V U, Thie A, Tilsner V, Philapitsch A, Schwarz H P, Webhof U, Müller A, Zeumer H

机构信息

Department of Neuroradiology, University Hospital Eppendorf, Hamburg, Germany.

出版信息

Neuroradiology. 1996 Feb;38(2):181-5. doi: 10.1007/BF00604816.

DOI:10.1007/BF00604816
PMID:8692437
Abstract

To improve the efficacy of local intraarterial fibrinolysis (LIF), we compared different fibrinolytic drugs in a cerebral circulation model in the laboratory. The technical efficacy of fibrinolysis, defined as the clot volume lysed per unit time, was found to be optimal with r-tissue plasminogen activator (TPA) activated lys-plasminogen (= plasmin). Subsequently, 20 patients with stroke due to carotid artery territory occlusion were treated by local intraarterial fibrinolysis using the plasmin regimen. The angiographic data and clinical outcome of these patients were compared with those of 40 patients who received plasminogen activators (urokinase or r-TPA) only. Laboratory and clinical data confirmed that plasmin lysis is superior to treatment using only plasminogen activators.

摘要

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本文引用的文献

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Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence.脑缺血后的出血性转化：机制与发生率
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Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus recombinant tissue plasminogen activator (r-TPA).中风患者的局部动脉内纤维蛋白溶解疗法：尿激酶与重组组织型纤溶酶原激活剂（r-TPA）对比
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Multicenter trial of hemodilution in ischemic stroke--background and study protocol. Scandinavian Stroke Study Group.
Stroke. 1985 Sep-Oct;16(5):885-90. doi: 10.1161/01.str.16.5.885.
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Intracarotid urokinase with thromboembolic occlusion of the middle cerebral artery.颈内动脉注射尿激酶治疗大脑中动脉血栓栓塞性闭塞
Stroke. 1988 Jul;19(7):802-12. doi: 10.1161/01.str.19.7.802.
8
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