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1
High efficiency, long-term clinical expression of cottontail rabbit papillomavirus (CRPV) DNA in rabbit skin following particle-mediated DNA transfer.颗粒介导的DNA转移后，棉尾兔乳头瘤病毒（CRPV）DNA在兔皮肤中的高效长期临床表达。
Nucleic Acids Res. 1996 Jul 1;24(13):2620-2. doi: 10.1093/nar/24.13.2620.
2
Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination: effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model.粒细胞-巨噬细胞集落刺激因子预刺激加乳头瘤病毒E6 DNA疫苗接种：对棉尾兔乳头瘤病毒-兔模型中乳头瘤形成和消退的影响
J Virol. 2000 Sep;74(18):8700-8. doi: 10.1128/jvi.74.18.8700-8708.2000.
3
Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA.携带EJ-ras DNA和棉尾兔乳头瘤病毒DNA的转基因兔中的乳头瘤和癌
J Virol. 1993 Mar;67(3):1698-701. doi: 10.1128/JVI.67.3.1698-1701.1993.
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Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge.用棉尾兔乳头瘤病毒的E6基因对兔子进行皮内接种可提供部分抗病毒攻击的保护作用。
Vaccine. 1998 Apr;16(6):613-23. doi: 10.1016/s0264-410x(97)84510-0.
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Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits.棉尾兔乳头瘤病毒DNA的甲基化及在转基因兔中的组织特异性表达
Virus Res. 1995 Jan;35(1):101-8. doi: 10.1016/0168-1702(94)00080-v.
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Infectious virus replication in papillomas induced by molecularly cloned cottontail rabbit papillomavirus DNA.分子克隆的棉尾兔乳头瘤病毒DNA诱导的乳头瘤中传染性病毒的复制
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The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo.病毒E4蛋白是棉尾兔乳头瘤病毒在体内完成生产性周期所必需的。
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Rabbits immunised with recombinant BCG expressing the cottontail rabbit papillomavirus (CRPV) L2E7E2 genes induces regression of established papillomas.用表达棉尾兔乳头瘤病毒（CRPV）L2E7E2基因的重组卡介苗免疫的兔子可使已形成的乳头瘤消退。
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High efficiency induction of papillomas in vivo using recombinant cottontail rabbit papillomavirus DNA.使用重组棉尾兔乳头瘤病毒DNA在体内高效诱导乳头瘤
J Virol Methods. 1995 Oct;55(2):233-44. doi: 10.1016/0166-0934(95)00062-y.
10
Free cottontail rabbit papillomavirus DNA persists in warts and carcinomas of infected rabbits and in cells in culture transformed with virus or viral DNA.游离的棉尾兔乳头瘤病毒DNA持续存在于受感染兔子的疣和癌组织中，以及用病毒或病毒DNA转化的培养细胞中。
Virology. 1983 Feb;125(1):127-38. doi: 10.1016/0042-6822(83)90069-7.

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The rabbit papillomavirus model: a valuable tool to study viral-host interactions.兔乳头瘤病毒模型：研究病毒-宿主相互作用的有价值工具。
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A novel recombinant papillomavirus genome enabling in vivo RNA interference reveals that YB-1, which interacts with the viral regulatory protein E2, is required for CRPV-induced tumor formation in vivo.一种能够在体内实现RNA干扰的新型重组乳头瘤病毒基因组显示，与病毒调节蛋白E2相互作用的YB-1是体内CRPV诱导肿瘤形成所必需的。
Am J Cancer Res. 2014 May 26;4(3):222-33. eCollection 2014.
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Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo.遗传变化对CRPV基因组的影响及其在体内发病机制研究中的应用。
Virology. 2007 Feb 20;358(2):384-90. doi: 10.1016/j.virol.2006.08.045. Epub 2006 Oct 4.
6
The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo.病毒E4蛋白是棉尾兔乳头瘤病毒在体内完成生产性周期所必需的。
J Virol. 2004 Feb;78(4):2142-51. doi: 10.1128/jvi.78.4.2142-2151.2004.
7
Identification of the E9/E2C cDNA and functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus.E9/E2C 互补 DNA 的鉴定及该基因产物的功能特性揭示了棉尾兔乳头瘤病毒中一种新的转录和复制抑制因子。
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8
A transactivator function of cottontail rabbit papillomavirus e2 is essential for tumor induction in rabbits.棉尾兔乳头瘤病毒E2的反式激活功能对于在兔体内诱导肿瘤至关重要。
J Virol. 2002 Nov;76(22):11209-15. doi: 10.1128/jvi.76.22.11209-11215.2002.
9
Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits.用棉尾兔乳头瘤病毒E8基因进行皮内DNA疫苗接种可诱导兔产生针对病毒攻击的保护性免疫。
J Virol. 2002 Jul;76(13):6453-9. doi: 10.1128/jvi.76.13.6453-6459.2002.
10
Low-volume jet injection for intradermal immunization in rabbits.用于家兔皮内免疫的小剂量喷射注射
BMC Biotechnol. 2002 May 23;2:10. doi: 10.1186/1472-6750-2-10.

本文引用的文献

1
Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts.乳头瘤病毒E7蛋白与视网膜母细胞瘤蛋白的结合对于病毒诱导疣的形成并非必需。
J Virol. 1993 Feb;67(2):716-25. doi: 10.1128/JVI.67.2.716-725.1993.
2
Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes.除了E6和E7转化基因外，棉尾兔乳头瘤病毒形成乳头瘤还需要E1和E2调控基因。
J Virol. 1994 Sep;68(9):6097-102. doi: 10.1128/JVI.68.9.6097-6102.1994.
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Epidermis: an attractive target tissue for gene therapy.表皮：基因治疗的一个有吸引力的靶组织。
J Invest Dermatol. 1994 Nov;103(5 Suppl):63S-69S. doi: 10.1111/1523-1747.ep12399070.
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Papilloma formation in human foreskin xenografts after inoculation of human papillomavirus type 16 DNA.接种人乳头瘤病毒16型DNA后人类包皮异种移植瘤中乳头瘤的形成。
J Virol. 1995 Apr;69(4):2716-21. doi: 10.1128/JVI.69.4.2716-2721.1995.
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Animal models of human-papillomavirus-associated oncogenesis.人乳头瘤病毒相关肿瘤发生的动物模型
Intervirology. 1994;37(3-4):189-200. doi: 10.1159/000150377.
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Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer.构建一种新型牛乳头瘤病毒载体，其无可检测的转化活性，适用于基因转移。
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Gene therapy's growing pains.基因治疗的成长烦恼。
Science. 1995 Aug 25;269(5227):1050, 1052-5. doi: 10.1126/science.7652552.
8
Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector.牛乳头瘤病毒脱氧核糖核酸：一种新型真核克隆载体。
Mol Cell Biol. 1981 Jun;1(6):486-96. doi: 10.1128/mcb.1.6.486-496.1981.
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The papillomavirus E2 regulatory proteins.乳头瘤病毒E2调节蛋白。
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10
Use of a rapid, efficient inoculation method to induce papillomas by cottontail rabbit papillomavirus DNA shows that the E7 gene is required.使用一种快速、高效的接种方法，通过棉尾兔乳头瘤病毒DNA诱导乳头瘤，结果表明E7基因是必需的。
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4816-20. doi: 10.1073/pnas.88.11.4816.

颗粒介导的DNA转移后，棉尾兔乳头瘤病毒（CRPV）DNA在兔皮肤中的高效长期临床表达。

High efficiency, long-term clinical expression of cottontail rabbit papillomavirus (CRPV) DNA in rabbit skin following particle-mediated DNA transfer.

作者信息

Xiao W, Brandsma J L

机构信息

Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520-8016, USA.

出版信息

Nucleic Acids Res. 1996 Jul 1;24(13):2620-2. doi: 10.1093/nar/24.13.2620.

DOI:10.1093/nar/24.13.2620
PMID:8692707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC145979/
Abstract

The ability of skin to support long lasting expression of genes delivered with a particle-mediated system was evaluated in rabbits inoculated with cottontail rabbit papillomavirus (CRPV) DNA. The optimal delivery force for maximal gene expression in rabbit skin was determined in transient beta-galactosidase assays. Forty-five sites in four rabbits were then inoculated at 350-400 p.s.i. with CRPV DNA. All sites (100%) formed papillomas with multiple papillomas at most sites. These results support the feasibility of using a particle-mediated delivery system for gene therapy and suggest that some papillomavirus features, such an origin of replication, may be well suited for use in vectors to target long term expression to skin.

摘要

在接种了棉尾兔乳头瘤病毒（CRPV）DNA的兔子中，评估了皮肤支持通过粒子介导系统递送的基因长期表达的能力。通过瞬时β-半乳糖苷酶测定法确定了兔皮肤中实现最大基因表达的最佳递送力。然后，在350-400磅力/平方英寸的压力下，对4只兔子的45个部位接种CRPV DNA。所有部位（100%）均形成了乳头瘤，大多数部位有多个乳头瘤。这些结果支持了使用粒子介导递送系统进行基因治疗的可行性，并表明某些乳头瘤病毒特征，如复制起点，可能非常适合用于载体，以实现皮肤的长期靶向表达。