Occhiato R, Schillaci O, Broglia L, Danieli R, Narilli P, Pavone P, Scopinaro F, Passariello R
Istituto di Radiologia, Università La Sapienza, Roma.
Radiol Med. 1996 May;91(5):581-4.
Our study was aimed at investigating the efficacy of scintigraphy with 99mTc-Sestamibi (MIBI) as a support to mammography and US in the diagnosis and staging of breast cancer. Twenty-seven women with breast lesions were examined: the masses, detected at mammography and US, ranged in diameter 0.7 to 2.5 cm; mass features suggested a benign lesion in 5 patients, a malignant lesion in 9 patients and a questionable diagnosis in 13 patients. 99mTc-MIBI scintigraphic images were analyzed blind by two observers and the pattern was considered positive when tracer uptake was demonstrated at the lesion. In neoplastic lesions, tracer uptake was looked for also in the axilla. All the patients were submitted to surgery and, in case of malignancy, lymphadenectomy was also performed. MIBI scintigraphy was negative in 14/16 benign lesions and positive in 9/11 malignant lesions. Tracer uptake in the axilla was observed in 3 of 5 patients with nodal involvement. Scintigraphy had 82% sensitivity, 87% specificity and 85% accuracy in the diagnosis of breast cancers.
我们的研究旨在探讨99m锝-甲氧基异丁基异腈（MIBI）闪烁扫描术作为乳房X线摄影和超声检查的辅助手段在乳腺癌诊断及分期中的有效性。对27例患有乳腺病变的女性进行了检查：在乳房X线摄影和超声检查中发现的肿块直径为0.7至2.5厘米；肿块特征提示5例为良性病变，9例为恶性病变，13例诊断存疑。两名观察者对99m锝-MIBI闪烁扫描图像进行了盲法分析，当病变处显示有示踪剂摄取时，则认为图像模式为阳性。对于肿瘤性病变，还在腋窝处寻找示踪剂摄取情况。所有患者均接受了手术，若为恶性肿瘤，还进行了淋巴结清扫术。MIBI闪烁扫描术在14/16例良性病变中呈阴性，在9/11例恶性病变中呈阳性。在5例有淋巴结受累的患者中，有3例在腋窝处观察到示踪剂摄取。闪烁扫描术在乳腺癌诊断中的敏感性为82%，特异性为87%，准确性为85%。
