[系统性红斑狼疮、进行性系统性硬化症和类风湿关节炎患者甲状腺功能的变化]

[Changes in thyroid function in systemic lupus erythematosus, progressive systemic sclerosis and rheumatoid arthritis].

作者信息

Sram K, Fustar V, Prus V, Kozul K

机构信息

Klinicka bolnica Osijek, Klinika za unutarnje bolesti, Osijek.

出版信息

Reumatizam. 1994;41(2):1-4.

PMID:8693195

Abstract

According to frequent thyroid function disorders in systemic connective tissue diseases a group of 380 patients were analysed - 70 with systemic erythematous lupus (SLE), 31 with progressive systemic scleris (PSS) and 270 with rheumatoid arthritis (RA). Thyroxine (T4) and triodothyronine (T3) were measured by radioimmunoassay technique and thyroid stimulating hormone (TSH) chronologically by monoclonal antibody technique and thereafter by fluoroimmunoassay. Thyreopahty was found at 15 patients with SLE (21.43%), 11 patients with PSS (35.48%) and 35 patients with RA (12.54%). Our results pointed out the significant frequency of thyroid function disorders in these diseases and imply the necessity of the routine thyroid function follow up, therefore to take adequate cure in due time.

摘要

根据系统性结缔组织疾病中常见的甲状腺功能紊乱情况，对一组380例患者进行了分析，其中70例患有系统性红斑狼疮（SLE），31例患有进行性系统性硬化症（PSS），270例患有类风湿性关节炎（RA）。采用放射免疫分析技术测定甲状腺素（T4）和三碘甲状腺原氨酸（T3），并先后采用单克隆抗体技术和荧光免疫分析技术按时间顺序测定促甲状腺激素（TSH）。在15例SLE患者（21.43%）、11例PSS患者（35.48%）和35例RA患者（12.54%）中发现了甲状腺病变。我们的结果指出了这些疾病中甲状腺功能紊乱的显著发生率，并意味着有必要对甲状腺功能进行常规随访，以便及时采取适当的治疗措施。