Volmer P A
National Animal Poison Control Center, College of Veterinary Medicine, Urbana, IL 61801, USA.
Vet Hum Toxicol. 1996 Apr;38(2):118-20.
Cisapride is an oral prokinetic agent used to facilitate or restore motility in the gastrointestinal tract. The National Animal Control Center has received 17 reports of accidental overexposure of dogs to cisapride since 1994. Doses of 640 mg/kg in dogs were reported to be lethal, but severe clinical signs have been noted at acute exposures as low as 18 mg/kg. The most common signs include diarrhea, muscle tremors and fasciculations, ataxia and incoordination, and hyperthermia. Available treatment is symptomatic and supportive. Activated charcoal is effective in reducing plasma cisapride levels.
西沙必利是一种口服促动力剂，用于促进或恢复胃肠道的蠕动。自1994年以来，国家动物控制中心已收到17起犬类意外过量接触西沙必利的报告。据报道，犬类摄入640毫克/千克的剂量可致死，但急性接触低至18毫克/千克时就已出现严重的临床症状。最常见的症状包括腹泻、肌肉震颤和肌束颤动、共济失调和不协调以及体温过高。现有的治疗方法是对症和支持治疗。活性炭可有效降低血浆中西沙必利的水平。
