Pedersen T K, Blaakaer J
Department of Obstetrics and Gynecology, Sønderborg Hospital, Denmark.
Acta Obstet Gynecol Scand. 1996 Jul;75(6):537-9. doi: 10.3109/00016349609054667.
To investigate the guidelines for patient selection and drug regimens for application of antibiotic prophylaxis in relation to cesarean section in the maternity clinics in Denmark.
A questionnaire to all the Danish maternity clinics that perform cesarean section, concerning indications for application of antibiotic prophylaxis and antibiotic regimens to patients undergoing acute and elective cesarean section.
All departments (n = 48) returned the questionnaire. Twenty departments (46%) provided written guidelines for antibiotic prophylaxis. Four departments (8%) used antibiotic prophylaxis to elective cesarean sections, 25 departments (52%) applied antibiotics to all emergency sections. In the presence of the rupture of membranes or prolongation of labor (> 12 hrs) 58% and 63% of the departments applied antibiotic prophylaxis, respectively. The most infrequent first choice drug was cefuroxim, employed by 27 departments (56%). Concerning timing, 21 departments (44%) applied antibiotics after cord clamping and 13 departments (27%) before incision.
We propose a nation-wide prospective investigation on the rate of infections associated with cesarean section to set up rational guidelines for antibiotic prophylaxis.
调查丹麦产科诊所剖宫产抗生素预防应用的患者选择指南和药物方案。
向所有进行剖宫产的丹麦产科诊所发放问卷，内容涉及急性和择期剖宫产患者抗生素预防应用的指征及抗生素方案。
所有科室（n = 48）均回复了问卷。20个科室（46%）提供了抗生素预防应用的书面指南。4个科室（8%）对择期剖宫产使用抗生素预防，25个科室（52%）对所有急诊剖宫产应用抗生素。在胎膜破裂或产程延长（> 12小时）的情况下，分别有58%和63%的科室应用抗生素预防。最不常用的首选药物是头孢呋辛，27个科室（56%）使用。关于用药时间，21个科室（44%）在脐带结扎后应用抗生素，13个科室（27%）在切开前应用。
我们建议在全国范围内对剖宫产相关感染率进行前瞻性调查，以制定合理的抗生素预防指南。
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