Muller F, Savey L, Le Fiblec B, Bussières L, Ndayizamba G, Colau J C, Giraudet P
Service de Biochimie, Hôpital Ambroise Paré, Boulogne, France.
Am J Obstet Gynecol. 1996 Jul;175(1):37-40. doi: 10.1016/s0002-9378(96)70247-8.
Our purpose was to study the correlation between maternal serum human chorionic gonadotropin levels measured at 15 to 18 weeks of amenorrhea and pregnancy-induced hypertension, preeclampsia, and small-for-gestational-age neonates.
Prospective trisomy 21 human chorionic gonadotropin screening data from 5776 patients were examined in a retrospective investigation of the relationship between human chorionic gonadotropin and pregnancy-induced hypertension (234 cases), preeclampsia (34 cases), and small-for-gestational-age neonates (238 cases).
Maternal serum human chorionic gonadotropin (multiples of the median) was higher in the three populations with pathologic disorders. This difference was statistically significant in patients with small-for-gestational-age neonates (p < 0.0163) and preeclampsia (p < 0.0001) but not in those with pregnancy-induced hypertension. In the preeclampsia subgroup, with a cutoff value of 2 multiples of the median, specificity was 32% and sensitivity was 10%; with a cutoff value of 1 multiples of the median, specificity was 100% and sensitivity was 50%.
High maternal serum human chorionic gonadotropin levels at 15 weeks are related to a risk for preeclampsia. Depending on the human chorionic gonadotropin cutoff value, 32% or 100% of preeclampsia patients would be selected. The usefulness of preventive aspirin treatment from the fifteenth week needs more investigation in a larger multicenter study of preeclampsia.
我们的目的是研究闭经15至18周时测定的孕妇血清人绒毛膜促性腺激素水平与妊娠高血压、先兆子痫和小于胎龄儿之间的相关性。
在一项关于人绒毛膜促性腺激素与妊娠高血压（234例）、先兆子痫（34例）和小于胎龄儿（238例）关系的回顾性研究中，检查了来自5776例患者的前瞻性21三体人绒毛膜促性腺激素筛查数据。
患有病理疾病的三组人群中，孕妇血清人绒毛膜促性腺激素（中位数倍数）较高。这种差异在小于胎龄儿患者（p < 0.0163）和先兆子痫患者（p < 0.0001）中具有统计学意义，但在妊娠高血压患者中无统计学意义。在先兆子痫亚组中，以中位数倍数2为临界值时，特异性为32%，敏感性为10%；以中位数倍数1为临界值时，特异性为100%，敏感性为50%。
孕15周时孕妇血清人绒毛膜促性腺激素水平升高与先兆子痫风险相关。根据人绒毛膜促性腺激素临界值，可筛选出32%或100%的先兆子痫患者。从第15周开始进行预防性阿司匹林治疗的有效性，需要在更大规模的先兆子痫多中心研究中进一步调查。
