Radbruch L, Grond S, Zech D J, Bischoff A
Department of Anaesthesiology, University of Cologne, Germany.
J Clin Anesth. 1996 Mar;8(2):144-50. doi: 10.1016/0952-8180(95)00201-4.
We present 12 case reports from patients treated with more than 600 mg of morphine per day. We found no "opioid-nonresponsive pain" under treatment with a combination of morphine and nonopioids, supplemented with coanalgesics where appropriate. Side effects of morphine therapy were controlled with adjuvant drugs. Serious adverse effects were not observed. Episodes of break-through pain, dysphagia, and dyspnea caused by far advanced cancer disease were seen frequently.
我们报告了12例每日接受超过600毫克吗啡治疗的患者病例。我们发现，在吗啡与非阿片类药物联合治疗并在适当情况下辅以辅助镇痛药的过程中，不存在“阿片类药物无反应性疼痛”。吗啡治疗的副作用通过辅助药物得到控制。未观察到严重不良反应。晚期癌症疾病引起的突破性疼痛、吞咽困难和呼吸困难发作很常见。
