Takeda M, Shibuya H, Inoue T
Department of Dental Radiology and Radiation Research, Tokyo Medical and Dental University, Japan.
Acta Oncol. 1996;35(4):463-7. doi: 10.3109/02841869609109923.
Gold-198 grain mold therapy was given to 27 patients with 29 oral cancers and the results were analysed. Single plane mold alone was chosen for treatment when the maximum thickness of the tumor was below 2 mm. For thicker tumors, external irradiation prior to mold therapy was added. The 5-year survival following these principles was 82%. Initial tumor control was obtained in all 27 lesions followed for more than 2 years but recurrence took place in 7 (26%). Of 20 patients whose primary lesion did not recur within 2 years, 6 subsequently required surgery (2 cases) or non-surgical treatment (4 cases) for bone complications. The results obtained by single plane mold therapy are encouraging, particularly with regard to gum cancers showing a minimum bone invasion, and should therefore be advocated for selected patients with oral carcinoma.
对27例患有29处口腔癌的患者进行了金-198粒模疗法，并对结果进行了分析。当肿瘤的最大厚度低于2毫米时，仅选择单平面模进行治疗。对于较厚的肿瘤，在模疗法之前增加外照射。按照这些原则，5年生存率为82%。在随访超过2年的所有27个病灶中均实现了初始肿瘤控制，但有7个（26%）发生了复发。在20例原发灶在2年内未复发的患者中，有6例随后因骨并发症需要手术（2例）或非手术治疗（4例）。单平面模疗法取得的结果令人鼓舞，特别是对于骨侵犯最小的牙龈癌，因此对于选定的口腔癌患者应提倡使用该疗法。
