Nojima Hitomi, Kaida Atsushi, Haraguchi Mihoko, Murase Mai, Hattori Mariko, Tomioka Hirofumi, Harada Hiroyuki, Yoshimura Ryoichi, Miura Masahiko
Department of Dental Radiology and Radiation Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8549, Japan.
Department of Advanced Prosthodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Oral Radiol. 2025 Aug 25. doi: 10.1007/s11282-025-00853-y.
Mold therapy using gold-198 grains (Au-mold therapy) is a radical treatment for early stage oral cancer owing to its localized delivery of radiation. Understanding the efficacy and limitations of Au-mold therapy is crucial for optimizing treatment protocols and enhancing outcomes. Thus, this study evaluated the treatment outcomes of Au-mold therapy in patients with hard palate and gingival cancer and assessed its feasibility as a therapeutic modality.
This retrospective study analyzed data from 37 cases with hard palate and gingival cancer who received Au-mold therapy alone. Treatment outcomes and complications were evaluated, and the dose distribution of Au-mold therapy was simulated using clinically available calculation systems.
A notable 5-year local control rate of approximately 80% was noted in primary cases, whereas recurrent cases exhibited lower local control rates. Severe oral mucositis was not observed, and late complications, such as osteoradionecrosis and oral ulceration, were infrequent following Au-mold therapy.
This study provides insights into the use of Au-mold therapy for oral cancer. Promising outcomes in primary cases suggest its potential as a treatment option. Future research should focus on innovative strategies to enhance the efficacy of Au-mold therapy in oral cancer management.
使用金-198粒子的模具疗法（金模具疗法）是早期口腔癌的一种根治性治疗方法，因其能实现局部放射治疗。了解金模具疗法的疗效和局限性对于优化治疗方案和提高治疗效果至关重要。因此，本研究评估了金模具疗法在硬腭和牙龈癌患者中的治疗效果，并评估了其作为一种治疗方式的可行性。
本回顾性研究分析了37例仅接受金模具疗法的硬腭和牙龈癌患者的数据。评估了治疗效果和并发症，并使用临床可用的计算系统模拟了金模具疗法的剂量分布。
原发性病例的5年局部控制率约为80%，而复发性病例的局部控制率较低。未观察到严重的口腔黏膜炎，金模具疗法后骨放射性坏死和口腔溃疡等晚期并发症也很少见。
本研究为金模具疗法在口腔癌中的应用提供了见解。原发性病例的良好结果表明其作为一种治疗选择的潜力。未来的研究应侧重于创新策略，以提高金模具疗法在口腔癌治疗中的疗效。
