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放射治疗线状硬斑病样基底细胞癌

Treatment of morphea-type basal cell carcinomas with radiation therapy.

作者信息

Bart R S, Kopf A W, Gladstein A H

出版信息

Arch Dermatol. 1977 Jun;113(6):783-6.

PMID:869549
Abstract

Eight patients received superficial x-ray therapy for morphea-type basal cell carcinomas. Seven lesions did not recur. One recurrence adjacent to an irradiated field was observed; it was considered to be a geographic miss and has led us to include a wider field (10 mm) of normal-appearing skin beyond the clinical perimeter of the tumor when the lesion is ill-defined. The cosmetic results after treatment were poorer than anticipated for this schedule of radiation therapy, based on our extensive experience with other types of basal cell carcinomas. To obtain the best long-term results we believe that, where technically feasible Mohs surgery and conventional surgical excision with histologic verification of free margins are the treatments of choice for morphea-type basal cell carcinomas. However, our experience indicates that morphea-type basal-cell carcinomas can be cured with radiation therapy; therefore, x-rays have a place in the armamentarium of therapeutic modalities for this tumor if surgery is not feasible or if it is refused by the patient.

摘要

8例局限性硬皮病样基底细胞癌患者接受了浅层X线治疗。7个病灶未复发。观察到1例在照射野附近复发;这被认为是一个边缘遗漏,这使我们在病灶边界不清时,在肿瘤临床边界之外纳入更宽(10毫米)的外观正常皮肤区域。基于我们对其他类型基底细胞癌的丰富经验,该放疗方案的治疗后美容效果比预期差。为了获得最佳的长期效果,我们认为,在技术可行的情况下,莫氏手术和对切缘进行组织学验证的传统手术切除是局限性硬皮病样基底细胞癌的首选治疗方法。然而,我们的经验表明,局限性硬皮病样基底细胞癌可以通过放疗治愈;因此,如果手术不可行或患者拒绝手术,X线在该肿瘤的治疗手段中占有一席之地。

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