FitzSimon J S, Mulvihill A, Kennedy S, Finch A, Collum L M, Eustace P
Department of Ophthalmology, University College Dublin.
Br J Ophthalmol. 1996 May;80(5):402-4. doi: 10.1136/bjo.80.5.402.
AIMS/BACKGROUND: To identify an HLA association with pseudoexfoliation of the lens capsule to support the hypothesis that there is a genetic predisposition to pseudoexfoliation. A randomised trial would be ideal for establishing a relation but is more costly and time consuming to conduct. Case-control studies provide an alternative method of establishing a relation.
The study group comprised 128 subjects who presented to a major eye centre with pseudoexfoliation. Data from blood donors representative of the population of Ireland were used to form a control group.
An HLA association with pseudoexfoliation is identified for 14 antigens. Eleven antigens (HLA A1, A33, B8, B47, B51, B53, B57, B62, DR3, DR12, and DR13) are significantly more common in the pseudoexfoliation group while three antigens (HLA B12, B17, and DR2) are significantly less common. Four HLA antigens are strongly associated, with odds ratios of over 7.5.
The strength of this HLA association is supportive evidence for a genetic component to the development of pseudoexfoliation of the lens capsule.
目的/背景：确定与晶状体囊假性剥脱相关的人类白细胞抗原（HLA），以支持晶状体囊假性剥脱存在遗传易感性这一假说。随机试验对于确立两者关系而言是理想选择，但实施起来成本更高且耗时更长。病例对照研究提供了另一种确立关系的方法。
研究组由128名因晶状体囊假性剥脱而就诊于一家大型眼科中心的受试者组成。来自爱尔兰人群中具有代表性的献血者数据被用于组建对照组。
确定了14种抗原与晶状体囊假性剥脱存在HLA相关性。11种抗原（HLA A1、A33、B8、B47、B51、B53、B57、B62、DR3、DR12和DR13）在晶状体囊假性剥脱组中显著更常见，而3种抗原（HLA B12、B17和DR2）显著更少见。4种HLA抗原具有强相关性，比值比超过7.5。
这种HLA相关性的强度为晶状体囊假性剥脱的发生存在遗传因素提供了支持性证据。
